Use of topical anti-inflammatory and antineoplastic agents in the treatment of young-aged actinic cheilitis: A systematic review.

Autor: Medeiros CKS; Postgraduate Program in Dental Sciences, Area of Concentration in Stomatology and Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil., de França GM; Postgraduate Program in Dental Sciences, Area of Concentration in Stomatology and Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil., Lima JGDC; Postgraduate Program in Dental Sciences, Area of Concentration in Stomatology and Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil., Pinheiro JC; Postgraduate Program in Dental Sciences, Area of Concentration in Experimental Biology, Federal University of Rio Grande do Norte, Natal, RN, Brazil., Almeida DRMF; Postgraduate Program in Dental Sciences, Area of Concentration in Experimental Biology, Federal University of Rio Grande do Norte, Natal, RN, Brazil., Santos PPA; Postgraduate Program in Dental Sciences, Area of Concentration in Stomatology and Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Jazyk: angličtina
Zdroj: Journal of cosmetic dermatology [J Cosmet Dermatol] 2022 Feb; Vol. 21 (2), pp. 473-481. Date of Electronic Publication: 2021 May 04.
DOI: 10.1111/jocd.14118
Abstrakt: Introduction: Several treatments have been used to reduce inflammation and to reverse epithelial alterations in actinic cheilitis (AC).
Aim: A systematic review was conducted to analyze the potential of topical treatments for remission and clinical improvement of AC as well as patient acceptability.
Methods: A systematic review of clinical trials was conducted following the PICO strategy to answer the following question: Are topical anti-inflammatory and antineoplastic agents effective in the treatment of actinic cheilitis? The quality of the studies was assessed by ROB-2, and the certainty of evidence was rated by GRADE guidelines.
Results: Eight clinical trials were selected, including four that investigated the use of anti-inflammatory drugs and four use of antineoplastic agents. The use of 3% diclofenac sodium was associated with partial remission of AC, while 5% imiquimod and ingenol mebutate promoted complete remission. Furthermore, 5% fluorouracil was the drug most associated with complications during treatment. Diclofenac sodium (3%) and fludroxycortide showed the best acceptance by the patients, especially in terms of symptom relief and comfort provided.
Conclusion: The anti-inflammatory and antineoplastic agents analyzed largely provided good clinical outcomes, with evidence of remission of AC lesions, development of few local adverse reactions during treatment, and good patient adherence.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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