Assessment of the biomarkers of hepatotoxicity following carbamazepine, levetiracetam, and carbamazepine-levetiracetam adjunctive treatment in male Wistar rats.

Autor:	Osuntokun OS; Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Osun State University Osogbo, Nigeria., Babatunde AA; Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Osun State University Osogbo, Nigeria., Olayiwola G; Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria., Atere TG; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, Osun State University, Osogbo, Nigeria., Oladokun OO; Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Osun State University Osogbo, Nigeria., Adedokun KI; Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Osun State University Osogbo, Nigeria.
Jazyk:	angličtina
Zdroj:	Toxicology reports [Toxicol Rep] 2021 Mar 10; Vol. 8, pp. 592-598. Date of Electronic Publication: 2021 Mar 10 (Print Publication: 2021).
DOI:	10.1016/j.toxrep.2021.03.008
Abstrakt:	Objective: This study examined some of the biomarkers of hepatotoxicity following chronic treatment with carbamazepine (CBZ), levetiracetam (LEV), and CBZ + LEV adjunctive treatment in male rats. Method: Twenty-four male Wistar rats (140-150 g) were randomized into four groups (n = 6) to receive oral dose of normal saline (0.1 mL), CBZ (25 mg/kg), LEV (50 mg/kg) or sub-therapeutic dose of CBZ (12.5 mg/kg) together with LEV (25 mg/kg) for 28 days. Activities of the liver enzymes and oxidative stress markers were determined while liver histomorphology was also carried out. Data were analyzed using descriptive and inferential statistics. The results were presented as mean ± SEM in graphs or tables, while the level of significance was taken at p < 0.05. Results: The activities of alkaline-phosphatase and malondialdehyde concentrations increased significantly in all the drug treatment groups, while the activities of superoxide dismutase decreased significantly following CBZ, and CBZ + LEV treatment. Alanine-aminotransferase activities increased significantly in the CBZ and CBZ + LEV treated rats compared with control. The liver section of CBZ treated rats showed mild vascular congestion. Conclusion: None of these AEDs treatment is devoid of hepatotoxicity. However, the adverse effects in CBZ were greater than LEV, or CBZ + LEV adjunctive treatment. Competing Interests: The authors report no declarations of interest. (© 2021 The Authors.)
Databáze:	MEDLINE
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