Prenatal developmental toxicity studies on fumes from oxidised asphalt (OA) in the rat.

Autor: Boogaard PJ; Shell Health, Shell International bv, PO Box 162, 2501 AN The Hague, The Netherlands; Toxicology Group in CONCAWE, Brussels, Belgium. Electronic address: peter.boogaard@shell.com., Buschmann J; General and Reproductive Toxicology Consultancy, Haegewiesen 93, 30657 Hannover, Germany; Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Straße 1, 30625 Hannover, Germany. Electronic address: jbuschm333@aol.com., Fuhst R; Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Straße 1, 30625 Hannover, Germany., Blümlein K; Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Straße 1, 30625 Hannover, Germany., Koch W; Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Straße 1, 30625 Hannover, Germany. Electronic address: wolfgang.koch@item.fraunhofer.de., Schaudien D; Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Straße 1, 30625 Hannover, Germany., Schwarz K; Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Straße 1, 30625 Hannover, Germany., McAlinden C; toXcel International, PO Box 93, Ledbury, Herefordshire HR8 9JE, United Kingdom. Electronic address: christine.mcalinden@toxcel.co.uk., Deferme L; ExxonMobil Petroleum and Chemical bv, Hermeslaan 2, 1831 Machelen, Belgium; Toxicology Group in CONCAWE, Brussels, Belgium. Electronic address: lize.deferme@exxonmobil.com., Vaissiere M; Total, 24 cours Michelet, 92800 Puteaux, France; Toxicology Group in CONCAWE, Brussels, Belgium. Electronic address: mathieu.vaissiere@total.com., Ketelslegers HB; CONCAWE, Vorstlaan 165, B-1160 Brussels, Belgium. Electronic address: hans.ketelslegers@concawe.eu., Steneholm A; Nynas, P.O. Box 10 700, SE-121 29 Stockholm, Sweden; Toxicology Group in CONCAWE, Brussels, Belgium. Electronic address: anna.steneholm@nynas.com.
Jazyk: angličtina
Zdroj: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2021 Jun; Vol. 102, pp. 67-79. Date of Electronic Publication: 2021 Mar 26.
DOI: 10.1016/j.reprotox.2021.03.003
Abstrakt: The prenatal developmental toxicity of the fumes of oxidised asphalt (OA) was tested by nose-only inhalation in the rat. The test material was generated by collecting fumes from the headspace of storage tanks filled with OA. The composition of these fumes was matched to fumes sampled at a workplace where the same OA was applied in a pour-and-roll operation, representing occupational exposure with high concentrations of fumes to not underestimate the possible hazard. In the main study, dams were exposed to 0, 53, 158 and 536 mg/m 3 of fume (as total organic mass), for 6 h/day for 19 days p.c. The maternal NOAEC was 53 mg/m³ (lowest dose tested). In the high-dose group treatment-related effects on body weight gain were seen. In the mid- and high-dose groups treatment-related effects on food consumption, lung weights, and histopathological changes in lungs and the upper respiratory tract were observed. The NOAEC for prenatal developmental toxicity was 536 mg/m³ since no exposure-related effects were found in any of the exposure groups for any of the investigated reproductive endpoints. Furthermore, nose-only exposure to OA fumes in concentrations up to 536 mg/m³ from days 1-19 p.c. did not induce any significant fetal abnormalities.
(Copyright © 2021. Published by Elsevier Inc.)
Databáze: MEDLINE
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