Persistent Immune Activation in Human Immunodeficiency Virus-Infected Pregnant Women Starting Combination Antiretroviral Therapy After Conception.

Autor:	Lohman-Payne B; Institute for Immunology and Informatics, Department of Cell and Molecular Biology, University of Rhode Island, Providence, Rhode Island, USA., Koster J; National Emerging Infectious Diseases Laboratories, Boston University Medical Campus, Boston, Massachusetts, USA., Gabriel B; Institute for Immunology and Informatics, Department of Cell and Molecular Biology, University of Rhode Island, Providence, Rhode Island, USA., Chilengi R; Center for Infectious Disease Research Zambia, Lusaka, Zambia., Forman LS; Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, Massachusetts, USA., Heeren T; Departments of Biostatistics, Boston, Massachusetts, USA., Duffy CR; Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Herlihy J; Department of Pediatrics, Boston, Massachusetts, USA., Crimaldi S; Department of Global Health, Boston University School of Public Health, Boston, Massachusetts, USA., Gill C; Department of Global Health, Boston University School of Public Health, Boston, Massachusetts, USA., Chavuma R; Department of Surgery, School of Medicine, University of Zambia, Lusaka, Zambia.; Right to Care-Zambia, Lusaka, Zambia., Mwananyanda L; Department of Global Health, Boston University School of Public Health, Boston, Massachusetts, USA.; Right to Care-Zambia, Lusaka, Zambia., Thea DM; Department of Global Health, Boston University School of Public Health, Boston, Massachusetts, USA.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2022 Apr 01; Vol. 225 (7), pp. 1162-1167.
DOI:	10.1093/infdis/jiab095
Abstrakt:	This study evaluated the impact of human immunodeficiency virus (HIV) and combination antiretroviral therapy (cART) on immune activation during pregnancy in a Zambian cohort of HIV-exposed but uninfected children followed up from birth. Activated CD8+ T cells (CD38+ and HLA-DR+) were compared among HIV-uninfected (n = 95), cART experienced HIV-infected (n = 111), and cART-naive HIV-infected (n = 21) pregnant women. Immune activation was highest among HIV-infected/cART-naive women but decreased during pregnancy. Immune activation HIV-infected women who started cART during pregnancy was reduced but not to levels similar to those in HIV-uninfected women. The effects of elevated maternal immune activation in pregnancy on subsequent infant health and immunity remain to be determined. (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.)
Databáze:	MEDLINE
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