Oropharyngeal meningococcal carriage in children and adolescents, a single center study in Buenos Aires, Argentina.

Autor: Gentile A; Epidemiology Division, Dr Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina., Della Latta MP; Epidemiology Division, Dr Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina., Bloch M; Epidemiology Division, Dr Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina., Martorelli L; Clinical Microbiology Service, INEI-ANLIS Dr. Carlos G. Malbrán, Buenos Aires, Argentina., Wisner B; Clinical Microbiology Service, INEI-ANLIS Dr. Carlos G. Malbrán, Buenos Aires, Argentina., Sorhouet Pereira C; Clinical Microbiology Service, INEI-ANLIS Dr. Carlos G. Malbrán, Buenos Aires, Argentina., Regueira M; Clinical Microbiology Service, INEI-ANLIS Dr. Carlos G. Malbrán, Buenos Aires, Argentina., Juarez MDV; Epidemiology Division, Dr Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina., Umido V; Epidemiology Division, Dr Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina., Efron A; Clinical Microbiology Service, INEI-ANLIS Dr. Carlos G. Malbrán, Buenos Aires, Argentina.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 Mar 29; Vol. 16 (3), pp. e0247991. Date of Electronic Publication: 2021 Mar 29 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0247991
Abstrakt: Background: Neisseria meningitidis (Nm) pharyngeal carriage is a necessary condition for invasive disease. We present the first carriage study in children in Buenos Aires, Argentina, considering 2017 as a transition year. Aims: to assess the rate of Nm carriage, to determine genogroup, clonal complex and outer membrane protein distribution, to determine carriage risk factors by age.
Methods: Cross-sectional study including children 1-17 yrs, at Ricardo Gutiérrez Children's Hospital in Buenos Aires 2017. Oro-pharyngeal swabs were taken and cultured within a short time after collection. Genogroup was determined by PCR and clonal complex by MLST. Categorical variables were analyzed.
Results: A total of 1,751 children were included. Group 1: 943 children 1-9 yrs, 38 Nm were isolated; overall carriage 4.0%. Genogroup distribution: B 26.3%, W 5.3%, Y 2.6%, Z 5.3%, other groups 7.9% and capsule null (cnl) 52.6%. Participating in extracurricular activities was the only independent predictor of Nm carriage. Group 2: 808 children 10-17 yrs, 76 Nm were isolated; overall carriage 9.4%. Genogroup distribution: B 19.7%, C 5.3%, W 7.9%, Y 9.2%, Z 5.3%, other groups 7.9% and cnl 44.7%. Independent predictors of carriage: attending pubs/night clubs and passive smoking (adjusted OR: 0.55, 95%CI = 0.32-0.93; p = 0.025).
Conclusions: Overall carriage was higher in 10-17 yrs. The isolates presenting the cnl locus were prevalent in both age groups and genogroup B was the second most frequent.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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