SARS-CoV-2 infection and smoking: What is the association? A brief review.

Autor:	Gupta I; College of Medicine, QU Health, Qatar University, Doha, Qatar.; Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar., Sohail MU; Proteomics Core, Weill Cornell Medicine, Qatar Foundation - Education City, P. O. Box 24144, Doha, Qatar., Elzawawi KE; College of Medicine, QU Health, Qatar University, Doha, Qatar., Amarah AH; College of Medicine, QU Health, Qatar University, Doha, Qatar., Vranic S; College of Medicine, QU Health, Qatar University, Doha, Qatar.; Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar., Al-Asmakh M; Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar.; Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.; Biomedical Research Center, QU Health, Qatar University, Doha, Qatar., Al Moustafa AE; College of Medicine, QU Health, Qatar University, Doha, Qatar.; Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar.; Biomedical Research Center, QU Health, Qatar University, Doha, Qatar.
Jazyk:	angličtina
Zdroj:	Computational and structural biotechnology journal [Comput Struct Biotechnol J] 2021; Vol. 19, pp. 1654-1660. Date of Electronic Publication: 2021 Mar 23.
DOI:	10.1016/j.csbj.2021.03.023
Abstrakt:	Susceptibility to severe illness from COVID-19 is anticipated to be associated with cigarette smoking as it aggravates the risk of cardiovascular and respiratory illness, including infections. This is particularly important with the advent of a new strain of coronaviruses, the severe acute respiratory syndrome coronavirus (SARS-CoV-2) that has led to the present pandemic, coronavirus disease 2019 (COVID-19). Although, the effects of smoking on COVID-19 are less described and controversial, we presume a link between smoking and COVID-19. Smoking has been shown to enhance the expression of the angiotensin-converting enzyme-2 ( ACE-2 ) and transmembrane serine protease 2 ( TMPRSS2 ) key entry genes utilized by SARS-CoV-2 to infect cells and induce a 'cytokine storm', which further increases the severity of COVID-19 clinical course. Nevertheless, the impact of smoking on ACE-2 and TMPRSS2 receptors expression remains paradoxical. Thus, further research is necessary to unravel the association between smoking and COVID-19 and to pursue the development of potential novel therapies that are able to constrain the morbidity and mortality provoked by this infectious disease. Herein we present a brief overview of the current knowledge on the correlation between smoking and the expression of SARS-CoV-2 key entry genes, clinical manifestations, and disease progression. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2021 The Author(s).)
Databáze:	MEDLINE
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