Postsurgical Pyoderma Gangrenosum in a Breast Cancer Patient: A Case Report and Literature Review.

Autor: Vernaci GM; Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.; Division of Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padua, Italy., Meroni M; Anaesthesiology Unit, Istituto Oncologico Veneto IRCCS, Padua, Italy., Dieci MV; Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.; Division of Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padua, Italy., Saibene T; Breast Surgery Unit, Istituto Oncologico Veneto IRCCS, Padua, Italy., Montesco MC; Anatomy and Histology Unit, Istituto Oncologico Veneto IRCCS, Padua, Italy., Orvieto E; Department of Pathology, Azienda Ospedaliera di Rovigo, Rovigo, Italy., Cattelan A; Unit of Infectious Disease, Department of Internal Medicine, Azienda Ospedaliera Universitaria di Padova, Padua, Italy., Ghiotto C; Division of Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padua, Italy., Miglietta F; Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.; Division of Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padua, Italy., Guarneri V; Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.; Division of Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padua, Italy., Cagol M; Breast Surgery Unit, Istituto Oncologico Veneto IRCCS, Padua, Italy.
Jazyk: angličtina
Zdroj: Case reports in oncology [Case Rep Oncol] 2021 Mar 01; Vol. 14 (1), pp. 160-164. Date of Electronic Publication: 2021 Mar 01 (Print Publication: 2021).
DOI: 10.1159/000509745
Abstrakt: Pyoderma gangrenosum is a rare skin necrotizing disease that can arise on a site of surgical trauma. Its pathogenesis has recently been related to dysregulation of the immune system, with inflammatory bowel disease representing the most commonly underlying systemic conditions. Several authors have also reported an association with solid malignancies (especially gastrointestinal and breast cancer). We describe the case of a 39-year-old patient diagnosed with a locally advanced, triple-negative breast cancer who developed a pyoderma gangrenosum on the surgical wound after a CVC implant with systemic complications. As the diagnosis and management of postsurgical pyoderma gangrenosum can be challenging for clinicians, underlying conditions as autoimmune disease and solid tumors have to be considered in order to guide treatment.
Competing Interests: The authors declare that they have no conflict of interest.
(Copyright © 2021 by S. Karger AG, Basel.)
Databáze: MEDLINE
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