Circulating nuclear factor-kappa B mediates cancer-associated inflammation in human breast and colon cancer.

Autor: Papila KB; Istanbul University-Cerrahpasa, Faculty of Cerrahpasa Medicine, Department of General Surgery, Istanbul, Turkey., Sozer V; Yildiz Technical University, Department of Biochemistry, Istanbul, Turkey., Cigdem KP; Istanbul University-Cerrahpasa, Faculty of Cerrahpasa Medicine, Department of General Surgery, Istanbul, Turkey., Durmus S; Istanbul University-Cerrahpasa, Faculty of Cerrahpasa Medicine, Department of Medical Biochemistry, Istanbul, Turkey., Kurtulus D; Istanbul University-Cerrahpasa, Faculty of Cerrahpasa Medicine, Istanbul, Turkey., Papila C; Istanbul University-Cerrahpasa, Faculty of Cerrahpasa Medicine, Department of Internal Medicine, Division of Oncology, Istanbul, Turkey., Gelisgen R; Istanbul University-Cerrahpasa, Faculty of Cerrahpasa Medicine, Department of Medical Biochemistry, Istanbul, Turkey., Uzun H; Istanbul University-Cerrahpasa, Faculty of Cerrahpasa Medicine, Department of Medical Biochemistry, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Journal of medical biochemistry [J Med Biochem] 2021 Mar 12; Vol. 40 (2), pp. 150-159.
DOI: 10.5937/jomb0-27128
Abstrakt: Background: Inflammation is recognized as a hallmark feature of cancer development and progression. The aim of our study was to investigate the significance of serum nuclear factor kappa-B (NF-κB) levels as a circulating marker in the monitoring of inflammation in breast and colon cancer; to show the relationship between NF-κB with inflammatory parameters as tumour necrosis factor-α (TNF-α), soluble TNF-related apoptosis-inducing ligand (sTRAIL), interleukin-6 (IL-6), pentraxin-3 (PTX-3), procalcitonin (PCT), and C-reactive protein (CRP) levels.
Methods: Serum NF-κB, TNF-α, sTRAIL, IL-6, PTX-3, PCT, and serum CRP levels were measured using enzyme-linked immunosorbent assay (ELISA) in 40 patients with breast cancer, 40 patients with colon cancer and 30 healthy controls.
Results: The serum NF-κB, TNF-α, IL-6, PTX-3, PCT, and serum CRP concentration was significantly higher, and the serum sTRAIL concentration was significantly lower in the patients with breast and colon cancer than in healthy controls. NF-κB was positively correlated with CRP and negatively correlated with sTRAIL.
Conclusions: These results suggest that increased NF-κB may decrease the clinical efficacy of sTRAIL in solid tumour cells. There is a relationship between inflammation and carcinogenesis so that the development of cancer occurs with chronic inflammation in breast and colon. The study results have shown that colon and breast cancer patients have increased systemic inflammation, as measured by increased circulating cytokines, and acute-phase proteins, or by abnormalities in circulating cells. NF-κB may combine with other markers of the systemic inflammatory response in prognostic scores in cancer. In addition to surgical resection of the tumour, and conventional radio and chemotherapy for cancer treatment, the use of sTRAIL or other agonists for cancer therapy appeared a new potential therapy.
Competing Interests: Conflict of Interest: The authors stated that they have no conflicts of interest regarding the publication of this article.
(2021 Kundaktepe Berrin Papila, Volkan Sozer, Kocael Pinar Cigdem, Sinem Durmus, Dilara Kurtulus, Cigdem Papila, Remise Gelisgen, Hafize Uzun, published by CEON/CEES.)
Databáze: MEDLINE
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