A role for medial entorhinal cortex in spatial and nonspatial forms of memory in rats.

Autor: Hales JB; Department of Psychological Sciences, University of San Diego, San Diego, CA, 92110, USA. Electronic address: jhales@sandiego.edu., Reitz NT; Marquette University School of Dentistry, Milwaukee, WI, 53233, USA., Vincze JL; Marian College of Osteopathic Medicine, Indianapolis, IN, 46222, USA., Ocampo AC; Department of Psychiatry, Yale University, New Haven, CT, 06511, USA., Leutgeb S; Neurobiology Section and Center for Neural Circuits and Behavior, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, 92093, USA; Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, CA, 92093, USA., Clark RE; Department of Psychiatry 0603, University of California, San Diego, La Jolla, CA, 92093, USA. Electronic address: reclark@ucsd.edu.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2021 Jun 11; Vol. 407, pp. 113259. Date of Electronic Publication: 2021 Mar 26.
DOI: 10.1016/j.bbr.2021.113259
Abstrakt: Many studies have focused on the role of the medial entorhinal cortex (MEC) in spatial memory and spatial processing. However, more recently, studies have suggested that the functions of the MEC may extend beyond the spatial domain and into the temporal aspects of memory processing. The current study examined the effect of MEC lesions on spatial and nonspatial tasks that require rats to learn and remember information about location or stimulus-stimulus associations across short temporal gaps. MEC- and sham-lesioned male rats were tested on a watermaze delayed match to position (DMP) task and trace fear conditioning (TFC). Rats with MEC lesions were impaired at remembering the platform location after both the shortest (1 min) and the longest (6 h) delays on the DMP task, never performing as precisely as sham rats under the easiest condition and performing poorly at the longest delay. On the TFC task, although MEC-lesioned rats were not impaired at remembering the conditioning context, they showed reduced freezing in response to the previously associated tone. These findings suggest that the MEC plays a role in bridging temporal delays during learning and memory that extend beyond its established role in spatial memory processing.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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