CA2 beyond social memory: Evidence for a fundamental role in hippocampal information processing.

Autor: Lehr AB; Department of Computational Neuroscience, University of Göttingen, Germany; Bernstein Center for Computational Neuroscience, University of Göttingen, Germany; Department of Computational Physiology, Simula Research Laboratory, Lysaker, Norway; Centre for Integrative Neuroplasticity, University of Oslo, Norway. Electronic address: andrew.lehr@phys.uni-goettingen.de., Kumar A; Department of Computational Science and Technology, KTH Royal Institute of Technology, Sweden., Tetzlaff C; Department of Computational Neuroscience, University of Göttingen, Germany; Bernstein Center for Computational Neuroscience, University of Göttingen, Germany., Hafting T; Centre for Integrative Neuroplasticity, University of Oslo, Norway; Institute of Basic Medical Sciences, University of Oslo, Norway., Fyhn M; Centre for Integrative Neuroplasticity, University of Oslo, Norway; Department of Biosciences, University of Oslo, Norway., Stöber TM; Department of Computational Physiology, Simula Research Laboratory, Lysaker, Norway; Centre for Integrative Neuroplasticity, University of Oslo, Norway; Department of Informatics, University of Oslo, Norway. Electronic address: tristan.stoeber@posteo.net.
Jazyk: angličtina
Zdroj: Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2021 Jul; Vol. 126, pp. 398-412. Date of Electronic Publication: 2021 Mar 26.
DOI: 10.1016/j.neubiorev.2021.03.020
Abstrakt: Hippocampal region CA2 has received increased attention due to its importance in social recognition memory. While its specific function remains to be identified, there are indications that CA2 plays a major role in a variety of situations, widely extending beyond social memory. In this targeted review, we highlight lines of research which have begun to converge on a more fundamental role for CA2 in hippocampus-dependent memory processing. We discuss recent proposals that speak to the computations CA2 may perform within the hippocampal circuit.
(Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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