Transient changes in white matter microstructure during general anesthesia.

Autor: Tang CY; BioMedical Engineering Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America., Wang VX; BioMedical Engineering Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America., Lun MY; BioMedical Engineering Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America., Mincer JS; Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer, New York, NY, United States of America., Ng JC; BioMedical Engineering Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America., Brallier JW; Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer, New York, NY, United States of America., Schwartz AE; Department of Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America., Ahn H; Department of Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America., McCormick PJ; Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer, New York, NY, United States of America., Nir T; Department of Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America., Delman B; BioMedical Engineering Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America., Sano M; Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer, New York, NY, United States of America., Deiner SG; Department of Anesthesiology, Dartmouth Hitchcock, Lebanon, NH, United States of America., Baxter MG; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 Mar 26; Vol. 16 (3), pp. e0247678. Date of Electronic Publication: 2021 Mar 26 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0247678
Abstrakt: Cognitive dysfunction after surgery under general anesthesia is a well-recognized clinical phenomenon in the elderly. Physiological effects of various anesthetic agents have been studied at length. Very little is known about potential effects of anesthesia on brain structure. In this study we used Diffusion Tensor Imaging to compare the white matter microstructure of healthy control subjects under sevoflurane anesthesia with their awake state. Fractional Anisotropy, a white mater integrity index, transiently decreases throughout the brain during sevoflurane anesthesia and then returns back to baseline. Other DTI metrics such as mean diffusivity, axial diffusivity and radial diffusivity were increased under sevoflurane anesthesia. Although DTI metrics are age dependent, the transient changes due to sevoflurane were independent of age and sex. Volumetric analysis shows various white matter volumes decreased whereas some gray matter volumes increased during sevoflurane anesthesia. These results suggest that sevoflurane anesthesia has a significant, but transient, effect on white matter microstructure. In spite of the transient effects of sevoflurane anesthesia there were no measurable effects on brain white matter as determined by the DTI metrics at 2 days and 7 days following anesthesia. The role of white matter in the loss of consciousness under anesthesia will need to be studied and MRI studies with subjects under anesthesia will need to take these results into account.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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