Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health.

Autor:	Kusuyama J; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA; Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Miyagi, Japan. Electronic address: joji.kusuyama.c1@tohoku.ac.jp., Alves-Wagner AB; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA., Conlin RH; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA., Makarewicz NS; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA., Albertson BG; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA., Prince NB; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA., Kobayashi S; Section of Immunobiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA., Kozuka C; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA; YCI Laboratory for Metabolic Epigenetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Møller M; Department of Gynecology and Obstetrics, Aarhus University Hospital and Clinical Institute, Aarhus University, Aarhus, Denmark., Bjerre M; Medical Research Laboratory, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Fuglsang J; Department of Gynecology and Obstetrics, Aarhus University Hospital and Clinical Institute, Aarhus University, Aarhus, Denmark., Miele E; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA., Middelbeek RJW; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA., Xiudong Y; Graduate School of Biomedical Sciences, University of Texas at Houston, Houston, TX, USA., Xia Y; Graduate School of Biomedical Sciences, University of Texas at Houston, Houston, TX, USA., Garneau L; Institut du Savoir Montfort, recherche, Ottawa, Canada; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada., Bhattacharjee J; School of Human Kinetics, Faculty of Health Science University of Ottawa, Ottawa, Canada., Aguer C; Institut du Savoir Montfort, recherche, Ottawa, Canada; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada; School of Human Kinetics, Faculty of Health Science University of Ottawa, Ottawa, Canada; Interdisciplinary School of Health Sciences, Faculty of Health Science University of Ottawa, Ottawa, Canada., Patti ME; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA., Hirshman MF; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA., Jessen N; Steno Diabetes Center Aarhus, Department of Biomedicine, Aarhus University, Aarhus, Denmark., Hatta T; Department of Anatomy, Kanazawa Medical University, Ishikawa, Japan., Ovesen PG; Department of Gynecology and Obstetrics, Aarhus University Hospital and Clinical Institute, Aarhus University, Aarhus, Denmark., Adamo KB; School of Human Kinetics, Faculty of Health Science University of Ottawa, Ottawa, Canada., Nozik-Grayck E; Cardiovascular Pulmonary Research Laboratories and Pediatric Critical Care, Department of Pediatrics, University of Colorado Anschutz Medical Center, Aurora, CO, USA., Goodyear LJ; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA. Electronic address: laurie.goodyear@joslin.harvard.edu.
Jazyk:	angličtina
Zdroj:	Cell metabolism [Cell Metab] 2021 May 04; Vol. 33 (5), pp. 939-956.e8. Date of Electronic Publication: 2021 Mar 25.
DOI:	10.1016/j.cmet.2021.03.004
Abstrakt:	Poor maternal diet increases the risk of obesity and type 2 diabetes in offspring, adding to the ever-increasing prevalence of these diseases. In contrast, we find that maternal exercise improves the metabolic health of offspring, and here, we demonstrate that this occurs through a vitamin D receptor-mediated increase in placental superoxide dismutase 3 (SOD3) expression and secretion. SOD3 activates an AMPK/TET signaling axis in fetal offspring liver, resulting in DNA demethylation at the promoters of glucose metabolic genes, enhancing liver function, and improving glucose tolerance. In humans, SOD3 is upregulated in serum and placenta from physically active pregnant women. The discovery of maternal exercise-induced cross talk between placenta-derived SOD3 and offspring liver provides a central mechanism for improved offspring metabolic health. These findings may lead to novel therapeutic approaches to limit the transmission of metabolic disease to the next generation. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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