Low-dose acetylsalicylic acid does not modify maternal vascular reactivity in nulliparas.
| Autor: | Andrade JAFM; Department of Women's, Child and Adolescent Health, Federal University of Ceará (UFC), Fortaleza-CE, Brazil., Silva RMD; Department of Nursing, Fortaleza University (UNIFOR), Fortaleza-CE, Brazil., Araujo Júnior E; Department of Obstetrics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo-SP, Brazil., Carvalho FHC; Department of Women's, Child and Adolescent Health, Federal University of Ceará (UFC), Fortaleza-CE, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2022 Dec; Vol. 35 (25), pp. 6029-6035. Date of Electronic Publication: 2021 Mar 26. |
| DOI: | 10.1080/14767058.2021.1904392 |
| Abstrakt: | Objective: To assess if the low-dose acetylsalicylic acid (ASA) would be capable of modifying endothelial function throughout pregnancy in nulliparous patients. Methods: A double-blind, randomized clinical trial with 277 were included. A total of 139 were orally administered 100 mg/day of ASA, and 138 received placebo. Endothelial function was assessed by flow-mediated dilation (FMD) in the brachial artery before the start of medication (11-14 weeks) and 20-24 and 30-34 weeks of gestation. The intervention was maintained until 34 weeks. The Mann-Whitney U test was used to compare the placebo and ASA groups. The comparison of FMD during pregnancy was performed using the Friedman test. Results: The groups (ASA and placebo) were similar regarding to age, weight, height, and body mass index (BMI) ( p > .005). The comparison of values of FMD (%) between placebo vs. ASA at 11 and 14 weeks (8.9 vs. 9.7%, p : .253), 20 and 24 weeks (8.8 vs. 10.7%, p : .152), and 30 and 34 weeks (10.7 vs. 9.8%, p : .314) did not show significant changes throughout pregnancy. We observed a significant prevalence of PE in the placebo regarding to ASA group [14 (10.2%) vs. 8 (5.8%), p : .171]. Conclusion: Acetylsalicylic acid did not modify the endothelial function assessed by FMD of the brachial artery during pregnancy in nulliparous women. |
| Databáze: | MEDLINE |
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