Beware of Drug Interactions Treating Iatrogenic Mycobacterium bovis Endocarditis from Intravesical BCG Instillation.

Autor: Curri F; Department of Experimental and Clinical Medical Sciences, Clinica Medica, University Hospital, University of Udine, Udine, Italy., Da Porto A; Department of Experimental and Clinical Medical Sciences, Clinica Medica, University Hospital, University of Udine, Udine, Italy., Casarsa V; Department of Experimental and Clinical Medical Sciences, Clinica Medica, University Hospital, University of Udine, Udine, Italy., Albini D; Department of Experimental and Clinical Medical Sciences, Clinica Medica, University Hospital, University of Udine, Udine, Italy., Minen G; Department of Cardiac Sciences, Cardiology, University Hospital, University of Udine, Udine, Italy., Sechi LA; Department of Experimental and Clinical Medical Sciences, Clinica Medica, University Hospital, University of Udine, Udine, Italy.
Jazyk: angličtina
Zdroj: European journal of case reports in internal medicine [Eur J Case Rep Intern Med] 2021 Feb 01; Vol. 8 (3), pp. 002263. Date of Electronic Publication: 2021 Feb 01 (Print Publication: 2021).
DOI: 10.12890/2021_002263
Abstrakt: We report a case of mechanical mitral valve endocarditis associated with miliary disseminated bacillus Calmette-Guerin (BCG) infection following intravesical instillations for minimally invasive bladder cancer in a 65-year-old man. The diagnosis was established by echocardiographic evidence of vegetation on the prosthetic mitral valve, miliary lesions in the lungs and evidence of bloodstream infection sustained by Mycobacterium . We successfully treated the patient with the classical regimen of quadruple antituberculous therapy.
Learning Points: To consider endocarditis as an extra-pulmonary manifestation of Mycobacterium bovis infection, especially in the presence of predisposing heart conditions and risk factors.To be careful of drug interactions among warfarin, rifampin and amiodarone.
Competing Interests: Conflicts of Interests: The Authors declare that there are no competing interests.
(© EFIM 2021.)
Databáze: MEDLINE