A symphony of destruction: Dynamic differential fibrinogenolytic toxicity by rattlesnake (Crotalus and Sistrurus) venoms.

Autor: Seneci L; Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia; Institute of Biology Leiden (IBL), Leiden University, 2333 BE Leiden, the Netherlands., Zdenek CN; Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia., Bourke LA; Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia., Cochran C; Department of Earth and Biological Sciences, Loma Linda University, Loma Linda, CA 92350, USA., Sánchez EE; National Natural Toxins Research Center (NNTRC), Department of Chemistry, Texas A&M University-Kingsville, MSC 224, 975 West Avenue B, Kingsville, TX 78363, USA., Neri-Castro E; Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnologa, Universidad Nacional Autónoma de México, Av. Universidad 2001, Cuernavaca, Morelos 62210, Mexico., Bénard-Valle M; Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnologa, Universidad Nacional Autónoma de México, Av. Universidad 2001, Cuernavaca, Morelos 62210, Mexico., Alagón A; Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnologa, Universidad Nacional Autónoma de México, Av. Universidad 2001, Cuernavaca, Morelos 62210, Mexico., Frank N; MToxins, 717 Oregon Street, Oshkosh, WI 54902, USA., Fry BG; Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. Electronic address: bgfry@uq.edu.au.
Jazyk: angličtina
Zdroj: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP [Comp Biochem Physiol C Toxicol Pharmacol] 2021 Jul; Vol. 245, pp. 109034. Date of Electronic Publication: 2021 Mar 22.
DOI: 10.1016/j.cbpc.2021.109034
Abstrakt: What factors influence the evolution of a heavily selected functional trait in a diverse clade? This study adopts rattlesnakes as a model group to investigate the evolutionary history of venom coagulotoxicity in the wider context of phylogenetics, natural history, and biology. Venom-induced clotting of human plasma and fibrinogen was determined and mapped onto the rattlesnake phylogenetic tree to reconstruct the evolution of coagulotoxicity across the group. Our results indicate that venom phenotype is often independent of phylogenetic relationships in rattlesnakes, suggesting the importance of diet and/or other environmental variables in driving venom evolution. Moreover, the striking inter- and intraspecific variability in venom activity on human blood highlights the considerable variability faced by physicians treating envenomation. This study is the most comprehensive effort to date to describe and characterize the evolutionary and biological aspects of coagulotoxins in rattlesnake venom. Further research at finer taxonomic levels is recommended to elucidate patterns of variation within species and lineages.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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