| Autor: |
Didier CM; University of Central Florida, Orlando, FL 32816, USA., Kundu A; University of Central Florida, Orlando, FL 32816, USA., Shoemaker JT; Lena Biosciences, Atlanta, GA 30332, USA., Vukasinovic J; Lena Biosciences, Atlanta, GA 30332, USA., Rajaraman S; University of Central Florida, Orlando, FL 32816, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems [J Microelectromech Syst] 2020 Oct; Vol. 29 (5), pp. 653-660. Date of Electronic Publication: 2020 Jun 26. |
| DOI: |
10.1109/jmems.2020.3003452 |
| Abstrakt: |
We have developed a new technology for the realization of composite biosensor systems, capable of measuring electrical and electrophysiological signals from electrogenic cells, using SeedEZ™ 3D cell culture-scaffold material. This represents a paradigm-shift for BioMEMS processing; 'Biology-Microfabrication' versus the standard 'Microfabrication-Biology' approach. An Interdigitated Electrode (IDE) developed on the 3D cell-scaffold was used to successfully monitor acute cardiomyocyte growth and controlled population decline. We have further characterized processability of the 3D scaffold, demonstrated long-term biocompatibility of the scaffold with various cell lines and developed a multifunctional layered biosensor composites (MLBCs) using SeedEZ™ and other biocompatible substrates for future multilayer sensor integration. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
