Porous Polymer Scaffolds based on Cross-Linked Poly-EGDMA and PLA: Manufacture, Antibiotics Encapsulation, and In Vitro Study.

Autor: Chesnokov SA; G. A. Razuvaev Institute of Organometallic Chemistry of Russian Academy of Sciences, Tropinina 49, Nizhny Novgorod, 603950, Russian Federation., Aleynik DY; G. A. Razuvaev Institute of Organometallic Chemistry of Russian Academy of Sciences, Tropinina 49, Nizhny Novgorod, 603950, Russian Federation.; Privolzhsky Research Medical University of the Ministry of Health Care of the Russian Federation, Minin and Pozharsky Square 10/1, Nizhny Novgorod, 603005, Russian Federation., Kovylin RS; G. A. Razuvaev Institute of Organometallic Chemistry of Russian Academy of Sciences, Tropinina 49, Nizhny Novgorod, 603950, Russian Federation., Yudin VV; G. A. Razuvaev Institute of Organometallic Chemistry of Russian Academy of Sciences, Tropinina 49, Nizhny Novgorod, 603950, Russian Federation., Egiazaryan TA; G. A. Razuvaev Institute of Organometallic Chemistry of Russian Academy of Sciences, Tropinina 49, Nizhny Novgorod, 603950, Russian Federation., Egorikhina MN; G. A. Razuvaev Institute of Organometallic Chemistry of Russian Academy of Sciences, Tropinina 49, Nizhny Novgorod, 603950, Russian Federation.; Privolzhsky Research Medical University of the Ministry of Health Care of the Russian Federation, Minin and Pozharsky Square 10/1, Nizhny Novgorod, 603005, Russian Federation., Zaslavskaya MI; Privolzhsky Research Medical University of the Ministry of Health Care of the Russian Federation, Minin and Pozharsky Square 10/1, Nizhny Novgorod, 603005, Russian Federation., Rubtsova YP; G. A. Razuvaev Institute of Organometallic Chemistry of Russian Academy of Sciences, Tropinina 49, Nizhny Novgorod, 603950, Russian Federation.; Privolzhsky Research Medical University of the Ministry of Health Care of the Russian Federation, Minin and Pozharsky Square 10/1, Nizhny Novgorod, 603005, Russian Federation., Gusev SA; Institute for Physics of Microstructures of Russian Academy of Sciences, Academicheskaya 7, Afonino, Nizhny Novgorod, 603087, Russian Federation., Mlyavykh SG; Privolzhsky Research Medical University of the Ministry of Health Care of the Russian Federation, Minin and Pozharsky Square 10/1, Nizhny Novgorod, 603005, Russian Federation., Fedushkin IL; G. A. Razuvaev Institute of Organometallic Chemistry of Russian Academy of Sciences, Tropinina 49, Nizhny Novgorod, 603950, Russian Federation.
Jazyk: angličtina
Zdroj: Macromolecular bioscience [Macromol Biosci] 2021 May; Vol. 21 (5), pp. e2000402. Date of Electronic Publication: 2021 Mar 23.
DOI: 10.1002/mabi.202000402
Abstrakt: Porous polymer materials derived from poly(ethylene glycol dimethacrylate) (poly-EGDMA) and antibiotic containing polylactide (PLA) are obtained for the first time. Porous poly-EGDMA monoliths with a system of open interconnected pores are synthesized by a visible light-induced radical polymerization of EGDMA in the presence of 70 wt% of porogenic agent, e.g., 1-butanol, 1-hexanol, 1-octanol, or cyclohexanol. The porosity of the obtained polymers is 75-78%. A modal pore size depends on the nature of the porogen and varies from 0.5 µm (cyclohexanol) to 12 µm (1-butanol). The polymer matrix made with 1-butanol features the presence of pores ranging from 1 to 100 µm. The pore surface of poly-EGDMA matrices is inlayered with poly-D,L-lactide (M n  23 × 10 3  Da, PDI 1.31). The PLA-modified poly-EGDMA retains a porous structure that is similar to the initial poly-EGDMA but with improved strength characteristics. The presence of antibiotic containing PLA ensures a high and continuous antibacterial activity of the hybrid polymeric material for 7 days. The nontoxicity of all the porous matrices studied makes them promising for clinical tests as osteoplastic materials.
(© 2021 Wiley-VCH GmbH.)
Databáze: MEDLINE
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