Coenzyme Q10 inhibits RANKL-induced osteoclastogenesis by regulation of mitochondrial apoptosis and oxidative stress in RAW264.7 cells.
Autor: | Zheng D; Department of Endocrinology, The Second Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China., Cui C; The Operative Surgery Laboratory, Bengbu Medical College, Bengbu, Anhui, China., Shao C; Department of Endocrinology, The Second Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China., Wang Y; Department of Endocrinology, The Second Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China., Ye C; Department of Endocrinology, The Second Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China., Lv G; Department of Endocrinology, The Second Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China. |
---|---|
Jazyk: | angličtina |
Zdroj: | Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2021 Jul; Vol. 35 (7), pp. e22778. Date of Electronic Publication: 2021 Mar 23. |
DOI: | 10.1002/jbt.22778 |
Abstrakt: | Coenzyme Q10 (CoQ10) has been reported to improve bone density and the number of trabeculae in postmenopausal osteoporosis, but the mechanism remains to be elucidated. We aimed to investigate the effects of CoQ10 on receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis and the underlying molecular mechanisms. RAW264.7 cells were treated with different concentrations of RANKL to differentiate into osteoclasts, and then these cells were treated with different concentrations of CoQ10 with or without H (© 2021 Wiley Periodicals LLC.) |
Databáze: | MEDLINE |
Externí odkaz: |