Magnetic graphene quantum dots facilitate closed-tube one-step detection of SARS-CoV-2 with ultra-low field NMR relaxometry.

Autor: Li Y; State Key Laboratory of Functional Materials of Informatics, Shanghai Institute of Microsystem and Information Technology (SIMIT), Chinese Academy of Sciences, Shanghai, 200050, PR China.; CAS Center for ExcelleNce in Superconducting Electronics (CENSE), Chinese Academy of Sciences, Shanghai, 200050, PR China.; Joint Research Institute on Functional Materials and Electronics, Collaboration between SIMIT and FZJ, Germany.; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences (UCAS), Beijing, 100049, PR China., Ma P; Shanghai Institute for Advanced Immunological Studies, ShanghaiTech University, Shanghai, 201210, PR China., Tao Q; State Key Laboratory of Functional Materials of Informatics, Shanghai Institute of Microsystem and Information Technology (SIMIT), Chinese Academy of Sciences, Shanghai, 200050, PR China.; CAS Center for ExcelleNce in Superconducting Electronics (CENSE), Chinese Academy of Sciences, Shanghai, 200050, PR China.; Joint Research Institute on Functional Materials and Electronics, Collaboration between SIMIT and FZJ, Germany.; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences (UCAS), Beijing, 100049, PR China., Krause HJ; Institute of Biological Information Processing (IBI-3), Forschungszentrum Jülich (FZJ), D-52425, Jülich, Germany.; Joint Research Institute on Functional Materials and Electronics, Collaboration between SIMIT and FZJ, Germany., Yang S; State Key Laboratory of Functional Materials of Informatics, Shanghai Institute of Microsystem and Information Technology (SIMIT), Chinese Academy of Sciences, Shanghai, 200050, PR China.; Joint Research Institute on Functional Materials and Electronics, Collaboration between SIMIT and FZJ, Germany.; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences (UCAS), Beijing, 100049, PR China., Ding G; State Key Laboratory of Functional Materials of Informatics, Shanghai Institute of Microsystem and Information Technology (SIMIT), Chinese Academy of Sciences, Shanghai, 200050, PR China.; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences (UCAS), Beijing, 100049, PR China., Dong H; State Key Laboratory of Functional Materials of Informatics, Shanghai Institute of Microsystem and Information Technology (SIMIT), Chinese Academy of Sciences, Shanghai, 200050, PR China.; CAS Center for ExcelleNce in Superconducting Electronics (CENSE), Chinese Academy of Sciences, Shanghai, 200050, PR China.; Joint Research Institute on Functional Materials and Electronics, Collaboration between SIMIT and FZJ, Germany.; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences (UCAS), Beijing, 100049, PR China., Xie X; State Key Laboratory of Functional Materials of Informatics, Shanghai Institute of Microsystem and Information Technology (SIMIT), Chinese Academy of Sciences, Shanghai, 200050, PR China.; CAS Center for ExcelleNce in Superconducting Electronics (CENSE), Chinese Academy of Sciences, Shanghai, 200050, PR China.; Joint Research Institute on Functional Materials and Electronics, Collaboration between SIMIT and FZJ, Germany.; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences (UCAS), Beijing, 100049, PR China.
Jazyk: angličtina
Zdroj: Sensors and actuators. B, Chemical [Sens Actuators B Chem] 2021 Jun 15; Vol. 337, pp. 129786. Date of Electronic Publication: 2021 Mar 15.
DOI: 10.1016/j.snb.2021.129786
Abstrakt: The rapid and sensitive diagnosis of the highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the crucial issues at the outbreak of the ongoing global pandemic that has no valid cure. Here, we propose a SARS-CoV-2 antibody conjugated magnetic graphene quantum dots (GQDs)-based magnetic relaxation switch (MRSw) that specifically recognizes the SARS-CoV-2. The probe of MRSw can be directly mixed with the test sample in a fully sealed vial without sample pretreatment, which largely reduces the testers' risk of infection during the operation. The closed-tube one-step strategy to detect SARS-CoV-2 is developed with home-made ultra-low field nuclear magnetic resonance (ULF NMR) relaxometry working at 118 μT. The magnetic GQDs-based probe shows ultra-high sensitivity in the detection of SARS-CoV-2 due to its high magnetic relaxivity, and the limit of detection is optimized to 248 Particles mL ‒1 . Meanwhile, the detection time in ULF NMR system is only 2 min, which can significantly improve the efficiency of detection. In short, the magnetic GQDs-based MRSw coupled with ULF NMR can realize a rapid, safe, and sensitive detection of SARS-CoV-2.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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