Effects of intravenous administration of recombinant Phα1β toxin in a mouse model of fibromyalgia.

Autor: Garcia Mendes MP; Nucleo de Pós-graduação, Instituto de Ensino e Pesquisa Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil., Carvalho Dos Santos D; Nucleo de Pós-graduação, Instituto de Ensino e Pesquisa Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil., Rezende MJS; Nucleo de Pós-graduação, Instituto de Ensino e Pesquisa Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil., Assis Ferreira LC; Nucleo de Pós-graduação, Instituto de Ensino e Pesquisa Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil., Rigo FK; Graduate Program in Health Sciences, University of the Extreme South of Santa Catarina (UNESC), Criciuma, SC, Brazil., José de Castro Junior C; Nucleo de Pós-graduação, Instituto de Ensino e Pesquisa Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil., Gomez MV; Nucleo de Pós-graduação, Instituto de Ensino e Pesquisa Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil. Electronic address: marcusvgomez@gmail.com.
Jazyk: angličtina
Zdroj: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2021 May; Vol. 195, pp. 104-110. Date of Electronic Publication: 2021 Mar 19.
DOI: 10.1016/j.toxicon.2021.03.012
Abstrakt: This study investigated the effects of intravenous (iv) administration of recombinant Phα1β toxin, pregabalin, and diclofenac by the intrathecal route using an animal model fibromyalgia (FM). The reserpine administration (0.25 mg/kg s. c) once daily for three consecutive days significantly induced hyperalgesia, immobility time, and sucrose consumption in mice on the 4th day. Reserpine caused hyperalgesia on the mechanical and thermal hyperalgesia on the 4th day was reverted by recombinant Phα1β (0.2 mg/kg iv) and pregabalin (1.25 μmol/site i. t) treatments. In contrast, diclofenac (215 nmol/site i. t) was ineffective. Recombinant Phα1β toxin, pregabalin, and diclofenac did not affect the depressive-like behavioural effect induced by reserpine on mice during the forced swim and sucrose consumption tests. The data confirmed the analgesic effect of the recombinant Phα1β toxin administered intravenously in a fibromyalgia mouse model.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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