| Autor: |
de Lima LB; Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Brazil.; Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Brazil., Viturino da Silva WA; Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Brazil., Silva SL; Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Brazil., Felipe Dos Santos EC; Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Brazil.; Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Brazil., Barbosa Machado JC; Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Brazil.; Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Brazil., Procópio TF; Biochemical Department, Federal University of Pernambuco, Recife, Brazil., de Moura MC; Biochemical Department, Federal University of Pernambuco, Recife, Brazil., Napoleão TH; Biochemical Department, Federal University of Pernambuco, Recife, Brazil., Assunção Ferreira MR; Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Brazil.; Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Brazil., Soares LAL; Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Brazil.; Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Brazil. |
| Abstrakt: |
The chemical composition, the antioxidant and antimicrobial potential of crude extract from leaves Cinnamomum verum and their enriched fractions was studied. Phytochemical analyses were performed by TLC and HPLC, and the antioxidant capacity was verified by DPPH • and ABTS •+ . The Minimal Inhibitory/Bactericidal Concentration was conducted against twenty-two bacteria to select five strains susceptible to extracts/fractions and resistant to the antibiotics tested. Interference of Ethyl Acetate Fraction (EAF) in resistance to synthetic antibiotic was assayed by modulatory and checkerboard model. The chromatographic data showed phenolic compounds in crude extract, as well the flavonoid enrichment in the EAF. The combination of EAF and synthetic antibiotics (ampicillin, azithromycin, ciprofloxacin, or gentamicin) provides a synergistic effect against multidrug resistant strains). The results are useful to obtain multi-targeting in a single therapy solution, which on antioxidants molecules plant-derivatives can act synergistically in antimicrobial combinations, a valuable aid as bacterial resistance modifying compounds. |
