Magnetic Microdevices for MRI-Based Detection of SARS-CoV-2 Viruses.

Autor:	Mair LO; Neuroparticle Corporation, North Bethesda, MD, USA., Hale O; Neuroparticle Corporation, North Bethesda, MD, USA., Jafari S; Weinberg are with Shape Theranostics, Inc. and Weinberg Medical Physics, Inc., North Bethesda, MD, USA., Chen C; Neuroparticle Corporation, North Bethesda, MD, USA., Udalov O; Neuroparticle Corporation, North Bethesda, MD, USA., Probst R; Neuroparticle Corporation, North Bethesda, MD, USA., Baum I; Neuroparticle Corporation, North Bethesda, MD, USA., Hevaganinge A; Neuroparticle Corporation, North Bethesda, MD, USA., Yi Wang E; Neuroparticle Corporation, North Bethesda, MD, USA., Rodriguez OC; Fricke are with Georgetown University., Albanese C; Fricke are with Georgetown University., Fricke ST; Fricke are with Georgetown University., Weinberg IN; Weinberg are with Shape Theranostics, Inc. and Weinberg Medical Physics, Inc., North Bethesda, MD, USA.
Jazyk:	angličtina
Zdroj:	IEEE open journal of engineering in medicine and biology [IEEE Open J Eng Med Biol] 2020; Vol. 1, pp. 265-267. Date of Electronic Publication: 2020 Sep 24.
DOI:	10.1109/ojemb.2020.3026234
Abstrakt:	Goal: To develop a micron-scale device that can operate as an MRI-based reporter for the presence of SARS-CoV-2 virus. Methods: Iron rod microdevices were constructed via template-guided synthesis and suspended in phosphate buffered saline (PBS). Heat-inactivated SARS-CoV-2 viruses were added to the samples and imaged with low-field MRI. Results: MRI of microdevices and viruses showed decreased signal intensity at low concentrations of viruses that recovered at higher concentrations. Electron micrographs suggest that reduced MRI intensity may be due to concentration-dependent shielding of water protons from local magnetic inhomogeneities caused by the iron microdevices. Conclusions: The preliminary results presented in this letter provide justification for further studies exploring the potential diagnostic role of magnetic microdevices in assessing the presence and concentration of SARS-CoV-2 viruses.
Databáze:	MEDLINE
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