Dual regulation of TxNIP by ChREBP and FoxO1 in liver.

Autor:	Noblet B; Université de Paris, Institut Cochin, CNRS, INSERM, 75014 Paris, France., Benhamed F; Université de Paris, Institut Cochin, CNRS, INSERM, 75014 Paris, France., O-Sullivan I; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612.; Medical Research Service, Jesse Brown VA Medical Center, Chicago, IL 60612, USA., Zhang W; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612.; Medical Research Service, Jesse Brown VA Medical Center, Chicago, IL 60612, USA., Filhoulaud G; Université de Paris, Institut Cochin, CNRS, INSERM, 75014 Paris, France., Montagner A; Toxalim, Université de Toulouse, INRA, ENVT, INP-Purpan, UPS, Toulouse 31027, France., Polizzi A; Toxalim, Université de Toulouse, INRA, ENVT, INP-Purpan, UPS, Toulouse 31027, France., Marmier S; Université de Paris, Institut Cochin, CNRS, INSERM, 75014 Paris, France., Burnol AF; Université de Paris, Institut Cochin, CNRS, INSERM, 75014 Paris, France., Guilmeau S; Université de Paris, Institut Cochin, CNRS, INSERM, 75014 Paris, France., Issad T; Université de Paris, Institut Cochin, CNRS, INSERM, 75014 Paris, France., Guillou H; Toxalim, Université de Toulouse, INRA, ENVT, INP-Purpan, UPS, Toulouse 31027, France., Bernard C; Institut de Recherches Servier, Noisy-le-Roi, Île-de-France, France., Unterman T; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612.; Medical Research Service, Jesse Brown VA Medical Center, Chicago, IL 60612, USA., Postic C; Université de Paris, Institut Cochin, CNRS, INSERM, 75014 Paris, France.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2021 Feb 20; Vol. 24 (3), pp. 102218. Date of Electronic Publication: 2021 Feb 20 (Print Publication: 2021).
DOI:	10.1016/j.isci.2021.102218
Abstrakt:	TxNIP (Thioredoxin-interacting protein) is considered as a potential drug target for type 2 diabetes. Although TxNIP expression is correlated with hyperglycemia and glucotoxicity in pancreatic β cells, its regulation in liver cells has been less investigated. In the current study, we aim at providing a better understanding of Txnip regulation in hepatocytes in response to physiological stimuli and in the context of hyperglycemia in db/db mice. We focused on regulatory pathways governed by ChREBP (Carbohydrate Responsive Element Binding Protein) and FoxO1 (Forkhead box protein O1), transcription factors that play central roles in mediating the effects of glucose and fasting on gene expression, respectively. Studies using genetically modified mice reveal that hepatic TxNIP is up-regulated by both ChREBP and FoxO1 in liver cells and that its expression strongly correlates with fasting, suggesting a major role for this protein in the physiological adaptation to nutrient restriction. Competing Interests: The authors declare no conflict of interest. (© 2021.)
Databáze:	MEDLINE
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