Night shift schedule alters endogenous regulation of circulating cytokines.
| Autor: | Liu PY; Division of Endocrinology, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.; David Geffen School of Medicine, University of California - Los Angeles, Los Angeles, CA, 90095, USA., Irwin MR; David Geffen School of Medicine, University of California - Los Angeles, Los Angeles, CA, 90095, USA.; Cousins Center for Psychoneuroimmunology, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California - Los Angeles, Los Angeles, CA, 90095, USA., Krueger JM; Department of Integrative Physiology and Neuroscience, Washington State University, Spokane, WA, 99202, USA., Gaddameedhi S; Department of Biological Sciences, North Carolina State University, Raleigh, NC, 27606, USA.; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, 27606, USA., Van Dongen HPA; Sleep and Performance Research Center, Washington State University, Spokane, WA, 99202, USA.; Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, 9202, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Neurobiology of sleep and circadian rhythms [Neurobiol Sleep Circadian Rhythms] 2021 Mar 05; Vol. 10, pp. 100063. Date of Electronic Publication: 2021 Mar 05 (Print Publication: 2021). |
| DOI: | 10.1016/j.nbscr.2021.100063 |
| Abstrakt: | Night shift work is a risk factor for viral infection, suggesting that night shift schedules compromise host defense mechanisms. Prior studies have investigated changes in the temporal profiles of circulating cytokines important for priming and restraining the immune response to infectious challenges from night shift work, but not by way of a 24-h constant routine of continuous wakefulness devoid of behavioral or environmental influences. Hence the true endogenous pattern of cytokines, and the combined effect of sleep loss and circadian misalignment on these cytokines remains unknown. Here, 14 healthy young men and women underwent three days of either a simulated night shift or a simulated day shift schedule under dim light in a controlled in-laboratory environment. This was followed by a 24-h constant routine protocol during which venous blood was collected at 3-h intervals. Those who had been in the night shift schedule showed lower mean circulating TNF-α (t Competing Interests: P.Y.L., M.R.I., J.M.K., S.G. and H.P.A.V.D have no financial or non-financial disclosures. (© 2021 The Authors. Published by Elsevier Inc.) |
| Databáze: | MEDLINE |
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