Study of microbiome changes in patients with ulcerative colitis in the Central European part of Russia.

Autor:	Gryaznova MV; Department of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia.; Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia., Solodskikh SA; Department of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia.; Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia., Panevina AV; Department of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia., Syromyatnikov MY; Department of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia.; Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia., Dvoretskaya YD; Department of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia.; Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia., Sviridova TN; Department of Hospital Therapy and Endocrinology, Voronezh State Medical University Named After N.N. Burdenko, 394036 Voronezh, Russia.; Family Medicine Center 'Olympus of Health', 394036 Voronezh, Russia., Popov ES; Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia., Popov VN; Department of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia.; Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2021 Mar 10; Vol. 7 (3), pp. e06432. Date of Electronic Publication: 2021 Mar 10 (Print Publication: 2021).
DOI:	10.1016/j.heliyon.2021.e06432
Abstrakt:	Ulcerative colitis (UC) is an inflammatory disease that affects the colon and rectum. Recently, evidence has emerged about the influence of microbiota on the development of this disease. However, studies on the role of intestinal microbiota in the pathogenesis of UC have been incomplete. In addition, there are no comprehensive studies of the causes of ulcerative colitis and data on the microbiological composition of the intestines of patients with ulcerative colitis in Russia. We carried out a study of the microbiological composition of the intestines of patients with ulcerative colitis and healthy individuals. We found significant changes in the bacteria genera and species in patients with UC compared with the control group using sequencing on the IonTorrent PGM system and subsequent data analysis. In our study we observed a significant increase of the genus Haemophilus, Olsenella, Prevotella, Cedecea, Peptostreptococcus, Faecalibacterium, Lachnospira, Negativibacillus, Butyrivibrio , and the species Bacteroides coprocola, Phascolarctobacterium succinatutens, Dialister succinatiphilus, Sutterella wadsworthensis, Faecalibacterium prausnitzii in patients with ulcerative colitis. In addition, in patients with ulcerative colitis there was a significant decrease in the genus Fusicatenibacter, Butyricimonas, Lactococcus, Eisenbergiella, Coprobacter, Cutibacterium, Falsochrobactrum, Brevundimonas, Yersinia, Leuconostoc and in the species Fusicatenibacter saccharivorans . We found confirmation of our data with literary sources and studies of UC. In addition, we discovered a few taxa such as Negativibacillus spp. and Falsochrobactrum spp. that have not been previously found in human stool samples. Our data confirm that more research is needed to understand the role of microbiome changes in the development of UC in different people populations. (© 2021 The Authors.)
Databáze:	MEDLINE
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