Increased choroidal thickness in adults with Down syndrome.

Autor: Csincsik L; Wellcome-Wolfson Institute for Experimental Medicine Queen's University Belfast Belfast UK., Nelson R; Wellcome-Wolfson Institute for Experimental Medicine Queen's University Belfast Belfast UK., Walpert MJ; Department of Psychiatry University of Cambridge, Cambridge Intellectual and Developmental Disabilities Research Group Cambridge UK., Peto T; Wellcome-Wolfson Institute for Experimental Medicine Queen's University Belfast Belfast UK., Holland A; Department of Psychiatry University of Cambridge, Cambridge Intellectual and Developmental Disabilities Research Group Cambridge UK., Lengyel I; Wellcome-Wolfson Institute for Experimental Medicine Queen's University Belfast Belfast UK.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia (Amsterdam, Netherlands) [Alzheimers Dement (Amst)] 2021 Mar 17; Vol. 13 (1), pp. e12170. Date of Electronic Publication: 2021 Mar 17 (Print Publication: 2021).
DOI: 10.1002/dad2.12170
Abstrakt: Introduction: People with Down syndrome (DS) are particularly susceptible to Alzheimer's disease (AD) due to the triplication of the amyloid precursor protein ( APP ) gene. In this cross-sectional study, we hypothesized that choroidal thinning reported in sporadic AD (sAD) is mirrored in adults with DS.
Methods: The posterior pole of the eye for 24 adults with DS and 16 age-matched controls (Ctrl) were imaged with optical coherence tomography. Choroidal thickness (ChT) was measured and analyzed in relation to cognitive status and cerebral amyloid beta (Aβ) load.
Results: ChT was increased in people with DS (pwDS) compared to Ctrl. This increase was associated with gender differences and positively correlated with cerebral Aβ load in a small subset. There was no significant correlation detected between ChT and age or cognitive status.
Discussion: In contrast to sAD this study found a significantly thicker choroid in pwDS. Whether these changes are related to Aβ pathology in DS needs further investigation.
Competing Interests: The authors declare no conflict of interests.
(© 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
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