Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection.

Autor: Song H; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA.; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA., Bose M; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA., Pinyakorn S; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA., Sanders-Buell E; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA., O'Sullivan AM; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA., Silas D; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA., Trichavaroj R; Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Nuntapinit B; Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Pham PT; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA., Akapirat S; Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Kroon E; SEARCH, Thai Red Cross Research Centre, Bangkok, Thailand., de Souza M; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA.; SEARCH, Thai Red Cross Research Centre, Bangkok, Thailand., Gramzinski R; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA., Michael NL; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Robb ML; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA., Vasan S; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA., Tovanabutra S; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA., Ananworanich J; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA.; SEARCH, Thai Red Cross Research Centre, Bangkok, Thailand.; Department of Global Health, Amsterdam University Medical Centers, University of Amsterdam, and Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2020 Sep 12; Vol. 7 (10), pp. ofaa429. Date of Electronic Publication: 2020 Sep 12 (Print Publication: 2020).
DOI: 10.1093/ofid/ofaa429
Abstrakt: We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.
(© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze: MEDLINE
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