Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach.

Autor: Chulián S; Department of Mathematics, Universidad de Cádiz, Puerto Real, Cádiz, Spain; Biomedical Research and Innovation Institute of Cádiz (INiBICA), Hospital Universitario Puerta del Mar, Cádiz, Spain. Electronic address: salvador.chulian@uca.es., Martínez-Rubio Á; Department of Mathematics, Universidad de Cádiz, Puerto Real, Cádiz, Spain; Biomedical Research and Innovation Institute of Cádiz (INiBICA), Hospital Universitario Puerta del Mar, Cádiz, Spain., Marciniak-Czochra A; Institute of Applied Mathematics, BioQuant and Interdisciplinary Center of Scientific Computing (IWR), Heidelberg University, Heidelberg, Germany., Stiehl T; Institute of Applied Mathematics, BioQuant and Interdisciplinary Center of Scientific Computing (IWR), Heidelberg University, Heidelberg, Germany., Goñi CB; Department of Paediatric Haematology and Oncology, Hospital de Jerez Cádiz, Spain., Rodríguez Gutiérrez JF; Department of Paediatric Haematology and Oncology, Hospital de Jerez Cádiz, Spain., Ramírez Orellana M; Department of Paediatric Haematology and Oncology, Hospital Infantil Universitario Niño Jesús, Instituto Investigación Sanitaria La Princesa, Madrid, Spain., Castillo Robleda A; Department of Paediatric Haematology and Oncology, Hospital Infantil Universitario Niño Jesús, Instituto Investigación Sanitaria La Princesa, Madrid, Spain., Pérez-García VM; Department of Mathematics, Mathematical Oncology Laboratory (MOLAB), Universidad de Castilla-La Mancha, Ciudad Real, Spain; Instituto de Matemática Aplicada a la Ciencia y la Ingeniería (IMACI), Universidad de Castilla-La Mancha, Ciudad Real, Spain; ETSI Industriales, Universidad de Castilla-La Mancha, Ciudad Real, Spain., Rosa M; Department of Mathematics, Universidad de Cádiz, Puerto Real, Cádiz, Spain; Biomedical Research and Innovation Institute of Cádiz (INiBICA), Hospital Universitario Puerta del Mar, Cádiz, Spain.
Jazyk: angličtina
Zdroj: Journal of theoretical biology [J Theor Biol] 2021 Aug 07; Vol. 522, pp. 110685. Date of Electronic Publication: 2021 Mar 19.
DOI: 10.1016/j.jtbi.2021.110685
Abstrakt: Haematopoiesis is the process of generation of blood cells. Lymphopoiesis generates lymphocytes, the cells in charge of the adaptive immune response. Disruptions of this process are associated with diseases like leukaemia, which is especially incident in children. The characteristics of self-regulation of this process make them suitable for a mathematical study. In this paper we develop mathematical models of lymphopoiesis using currently available data. We do this by drawing inspiration from existing structured models of cell lineage development and integrating them with paediatric bone marrow data, with special focus on regulatory mechanisms. A formal analysis of the models is carried out, giving steady states and their stability conditions. We use this analysis to obtain biologically relevant regions of the parameter space and to understand the dynamical behaviour of B-cell renovation. Finally, we use numerical simulations to obtain further insight into the influence of proliferation and maturation rates on the reconstitution of the cells in the B line. We conclude that a model including feedback regulation of cell proliferation represents a biologically plausible depiction for B-cell reconstitution in bone marrow. Research into haematological disorders could benefit from a precise dynamical description of B lymphopoiesis.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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