Efficacy of dietary nitrate-rich beetroot juice supplementation in patients with chronic obstructive pulmonary disease (COPD): A systematic review and meta-analysis.

Autor: Alshafie S; Faculty of Medicine, Suez-canal University, Egypt; International Medical Students' Research Association IMedRA, Egypt., El-Helw GO; Faculty of Medicine, Beni Suef University, Egypt; International Medical Students' Research Association IMedRA, Egypt., Fayoud AM; Faculty of Pharmacy, Kafr El-Shaikh University, Egypt; International Medical Students' Research Association IMedRA, Egypt., Elrashedy AA; Faculty of Medicine, Kafr El-Shaikh University, Egypt; International Medical Students' Research Association IMedRA, Egypt., Gbreel MI; Faculty of Medicine, 6-October University, Egypt; International Medical Students' Research Association IMedRA, Egypt., Alfayoumi SS; Faculty of Medicine, University of Jordan, Jordan; International Medical Students' Research Association IMedRA, Egypt., Mohamed IM; Faculty of Pharmacy, Beni Suef University, Egypt; International Medical Students' Research Association IMedRA, Egypt., Abdelwadoud GT; Faculty of Medicine, Fayoum University, Egypt; International Medical Students' Research Association IMedRA, Egypt., Isa AS; Faculty of Medicine, Al-Azhar University, Damietta, Egypt; International Medical Students' Research Association IMedRA, Egypt., Ragab KM; Faculty of Medicine, Minia University, Egypt; International Medical Students' Research Association IMedRA, Egypt., Nourelden AZ; Faculty of Medicine, Al-Azhar University, Cairo, Egypt; International Medical Students' Research Association IMedRA, Egypt. Electronic address: anas.zakarya25@gmail.com.
Jazyk: angličtina
Zdroj: Clinical nutrition ESPEN [Clin Nutr ESPEN] 2021 Apr; Vol. 42, pp. 32-40. Date of Electronic Publication: 2021 Feb 06.
DOI: 10.1016/j.clnesp.2021.01.035
Abstrakt: Background: Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory lung disease causing airflow obstruction from the lungs reducing exercise tolerance. It is one of the leading causes of respiratory dysfunction worldwide. Nitric Oxide (NO) may have a significant role in this inflammatory reaction to improve exercise capacity.
Aim: To evaluate the effect of dietary nitrate ingestion for COPD patients.
Methods: We searched Scopus, PubMed, Cochrane, and Web of Science databases till August 2020 and updated the search in December 2020 using relevant keywords. All search results were screened for eligibility. We extracted the data from the included articles and pooled them as mean difference (MD) with a 95% confidence interval (CI), using Review Manager software (ver. 5.4).
Results: A pooled analysis from eight included trials showed no significant difference between dietary nitrate-rich beetroot juice and placebo in systolic blood pressure, diastolic blood pressure, heart rate, 6-min walk test, cycling ergometry endurance time, and maximum rate of oxygen consumption (VO 2 ). On the other hand, nitrate-rich beetroot juice significantly increased the Borg Rating of Perceived Exertion (RPE) scale more than the placebo (MD = -0.77; 95% CI [0.18, 1.37], P = 0.01).
Conclusion: There is no significant effect of nitrate-rich beetroot juice on cardiovascular events as systolic, diastolic blood pressure, and heart rate, or exercise performance as 6-min walk test, and cycling ergometry endurance time, or maximum rate of oxygen consumption (VO 2 ). On the other hand, nitrate-rich beetroot juice improves the Borg Rating of Perceived Exertion (RPE) scale reflecting an increased exercise and physical activity level.
(Copyright © 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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