Development of brain atlases for early-to-middle adolescent collision-sport athletes.

Autor:	Zou Y; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.; College of Veterinary Medicine, Purdue University, West Lafayette, IN, 47907, USA., Zhu W; Department of Statistics, Purdue University, West Lafayette, IN, 47907, USA., Yang HC; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA., Jang I; School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, 47907, USA., Vike NL; Department of Basic Medical Sciences, Purdue University, West Lafayette, IN, 47907, USA., Svaldi DO; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA., Shenk TE; School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, 47907, USA., Poole VN; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.; Department of Basic Medical Sciences, Purdue University, West Lafayette, IN, 47907, USA., Breedlove EL; School of Mechanical Engineering, Purdue University, West Lafayette, IN, 47907, USA., Tamer GG Jr; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA., Leverenz LJ; Department of Health and Kinesiology, Purdue University, West Lafayette, IN, 47907, USA., Dydak U; School of Health Sciences, Purdue University, West Lafayette, IN, 47907, USA., Nauman EA; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.; Department of Basic Medical Sciences, Purdue University, West Lafayette, IN, 47907, USA.; School of Mechanical Engineering, Purdue University, West Lafayette, IN, 47907, USA., Tong Y; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA., Talavage TM; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.; School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, 47907, USA., Rispoli JV; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA. jrispoli@purdue.edu.; School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, 47907, USA. jrispoli@purdue.edu.
Jazyk:	angličtina
Zdroj:	Scientific reports [Sci Rep] 2021 Mar 19; Vol. 11 (1), pp. 6440. Date of Electronic Publication: 2021 Mar 19.
DOI:	10.1038/s41598-021-85518-6
Abstrakt:	Human brains develop across the life span and largely vary in morphology. Adolescent collision-sport athletes undergo repetitive head impacts over years of practices and competitions, and therefore may exhibit a neuroanatomical trajectory different from healthy adolescents in general. However, an unbiased brain atlas targeting these individuals does not exist. Although standardized brain atlases facilitate spatial normalization and voxel-wise analysis at the group level, when the underlying neuroanatomy does not represent the study population, greater biases and errors can be introduced during spatial normalization, confounding subsequent voxel-wise analysis and statistical findings. In this work, targeting early-to-middle adolescent (EMA, ages 13-19) collision-sport athletes, we developed population-specific brain atlases that include templates (T1-weighted and diffusion tensor magnetic resonance imaging) and semantic labels (cortical and white matter parcellations). Compared to standardized adult or age-appropriate templates, our templates better characterized the neuroanatomy of the EMA collision-sport athletes, reduced biases introduced during spatial normalization, and exhibited higher sensitivity in diffusion tensor imaging analysis. In summary, these results suggest the population-specific brain atlases are more appropriate towards reproducible and meaningful statistical results, which better clarify mechanisms of traumatic brain injury and monitor brain health for EMA collision-sport athletes.
Databáze:	MEDLINE
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