Ventricular Assist Device Driveline Infection and Development of Intracranial Hemorrhage: A Case Series.

Autor:	Prince AJ; From the Department of Internal Medicine, Lenox Hill Hospital, New York City, New York., Domenico CM; Department of Medicine, Cardiovascular Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Shore S; Department of Cardiology, University of Michigan, Ann Arbor, Michigan., Urgo KA; Department of Medicine, Cardiovascular Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Atluri P; Cardiothoracic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Wald JW; Department of Medicine, Cardiovascular Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Birati EY; Department of Medicine, Cardiovascular Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Jazyk:	angličtina
Zdroj:	ASAIO journal (American Society for Artificial Internal Organs : 1992) [ASAIO J] 2021 Nov 01; Vol. 67 (11), pp. e198-e200.
DOI:	10.1097/MAT.0000000000001409
Abstrakt:	Durable left ventricular assist devices (LVAD) are frequently complicated by driveline infection. The objective of this case series was to examine whether an association exists between driveline infection and intracranial hemorrhage. This retrospective case series included patients at a single tertiary care hospital on durable LVAD support who developed intracranial hemorrhage. Physical examination data, vital signs, and laboratory markers of sepsis including blood cultures and imaging of driveline sites were reviewed. A total of nine patients were included in the case series. At the time of hemorrhagic event, five patients had active driveline infection, and five patients were found to be bacteremic. All bacteremic patients were found to have supratherapeutic INR at the time of presentation. Although five patients experienced subarachnoid hemorrhage, only one patient was found to have a cerebral aneurysm. This case series highlights a possible association between LVAD driveline infection and intracranial hemorrhage, and the need for further research to better understand the pathophysiology driving this association. Competing Interests: Disclosure: Birati - Medtronic Inc - Research support paid to the University; Impulse Dynamics - Research support paid to the University. The other authors have no conflicts of interest to report. (Copyright © ASAIO 2021.)
Databáze:	MEDLINE
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