HIV-positive patients with oral Kaposi's sarcoma: An overall survival analysis of 31 patients.

Autor: Guedes PTL; Oral Diagnosis Department (Pathology and Semiology), Piracicaba Dental School, University of Campinas, Piracicaba, Brazil; Oral Pathology Department, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil., Pontes FSC; Oral Pathology Department, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil., Prado-Ribeiro AC; Oral Diagnosis Department (Pathology and Semiology), Piracicaba Dental School, University of Campinas, Piracicaba, Brazil; Dental Oncology Service, Instituto do Câncer do Estado de São Paulo (ICESP-FMUSP), São Paulo, Brazil., Rodrigues-Oliveira L; Oral Diagnosis Department (Pathology and Semiology), Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Brandão TB; Dental Oncology Service, Instituto do Câncer do Estado de São Paulo (ICESP-FMUSP), São Paulo, Brazil., de Souza LL; Oral Diagnosis Department (Pathology and Semiology), Piracicaba Dental School, University of Campinas, Piracicaba, Brazil; Oral Pathology Department, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil., Alves BWG; Oral Pathology Department, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil., Lopes MA; Oral Diagnosis Department (Pathology and Semiology), Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Santos-Silva AR; Oral Diagnosis Department (Pathology and Semiology), Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Monteiro JCMS; Infectious and Parasitic Diseases, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil., de Almeida OP; Oral Diagnosis Department (Pathology and Semiology), Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Pontes HAR; Oral Diagnosis Department (Pathology and Semiology), Piracicaba Dental School, University of Campinas, Piracicaba, Brazil; Oral Pathology Department, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil. Electronic address: Harp@ufpa.br.
Jazyk: angličtina
Zdroj: Oral surgery, oral medicine, oral pathology and oral radiology [Oral Surg Oral Med Oral Pathol Oral Radiol] 2021 Jun; Vol. 131 (6), pp. 702-710. Date of Electronic Publication: 2020 Nov 20.
DOI: 10.1016/j.oooo.2020.11.007
Abstrakt: Objective: The aim of this study was to evaluate the influence of viral load and lymphocyte count on survival of patients who presented with human immunodeficiency virus (HIV)-associated oral Kaposi's sarcoma.
Study Design: Thirty-one cases (from January 2010 to December 2019) of oral Kaposi's sarcoma in patients with HIV from 2 oral pathology centers in Brazil were reviewed, considering clinical data and correlation of viral load and lymphocyte count with overall survival. Overall survival rates were estimated by a Kaplan-Meier analysis and compared using a log-rank test. The factors introduced stepwise into a Cox proportional hazard model to identify the independent predictors of survival. A P value <.05 was considered significant.
Results: Most of the patients were males (90.3%) with a mean age of 32.4 years (range, 19-58). Hard palate, soft palate, and tongue were the most affected sites. Treatment, viral load >999 copies/mL, CD4 + level ≤200 cells/mm 3 , CD4 + /CD8 + level ≤0.39 cells/mm 3 , and CD4 + nadir level <50 cells/mm 3 were related to overall survival.
Conclusions: Survival of patients affected by oral HIV-associated Kaposi's sarcoma is influenced by treatment, viral load, CD4 + , CD4 + /CD8 + , and CD4 + nadir count.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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