TopBP1 comes into focus.
| Autor: | Dunphy WG; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: dunphy@caltech.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Molecular cell [Mol Cell] 2021 Mar 18; Vol. 81 (6), pp. 1126-1127. |
| DOI: | 10.1016/j.molcel.2021.02.027 |
| Abstrakt: | Frattini et al. (2021) demonstrate that TopBP1 forms phase-separated nuclear condensates to promote activation of ATR in cells experiencing genomic stress. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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