Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study.

Autor: Villar J; Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK. jose.villar@wrh.ox.ac.uk.; Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK. jose.villar@wrh.ox.ac.uk., Gunier RB; Center for Environmental Research and Children's Health, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Tshivuila-Matala COO; Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.; SAMRC Developmental Pathways For Health Research Unit, Department of Paediatrics & Child Health, University of the Witwatersrand, Johannesburg, South Africa.; Health, Nutrition & Population Global Practice, World Bank Group, Washington, DC, USA., Rauch SA; Center for Environmental Research and Children's Health, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Nosten F; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine Research building, University of Oxford Old Road Campus, Oxford, UK.; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand., Ochieng R; Faculty of Health Sciences, Aga Khan University, Nairobi, Kenya., Restrepo-Méndez MC; Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.; Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK., McGready R; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Barros FC; Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Pelotas, Brazil., Fernandes M; Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.; Faculty of Medicine, Department of Paediatrics, University of Southampton, Southampton, UK., Carrara VI; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Victora CG; Programa de Pós-Graduação em Epidemiologia, Universidade Federal de Pelotas, Pelotas, Brazil., Munim S; Department of Obstetrics and Gynaecology, Division of Women and Child Health, Aga Khan University, Karachi, Pakistan., Craik R; Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK., Barsosio HC; KEMRI-Coast Centre for Geographical Medicine and Research, University of Oxford, Kilifi, Kenya., Carvalho M; Department of Obstetrics & Gynaecology, Faculty of Health Sciences, Aga Khan University Hospital, Nairobi, Kenya., Berkley JA; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; KEMRI/Wellcome Trust Research Programme, Nairobi, Kenya., Cheikh Ismail L; Clinical Nutrition and Dietetics Department, University of Sharjah, Sharjah, United Arab Emirates., Norris SA; SAMRC Developmental Pathways For Health Research Unit, Department of Paediatrics & Child Health, University of the Witwatersrand, Johannesburg, South Africa., Ohuma EO; Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.; Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, UK., Stein A; Department of Psychiatry, University of Oxford, Oxford, UK.; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Lambert A; Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.; Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK., Winsey A; Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK., Uauy R; Department of Nutrition and Public Health Interventions Research, London School of Hygiene & Tropical Medicine, London, UK., Eskenazi B; Center for Environmental Research and Children's Health, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Bhutta ZA; Center for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada., Papageorghiou AT; Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.; Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK., Kennedy SH; Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.; Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK.
Jazyk: angličtina
Zdroj: Nature medicine [Nat Med] 2021 Apr; Vol. 27 (4), pp. 647-652. Date of Electronic Publication: 2021 Mar 18.
DOI: 10.1038/s41591-021-01280-2
Abstrakt: Many observational studies and some randomized trials demonstrate how fetal growth can be influenced by environmental insults (for example, maternal infections) 1 and preventive interventions (for example, multiple-micronutrient supplementation) 2 that can have a long-lasting effect on health, growth, neurodevelopment and even educational attainment and income in adulthood 3 . In a cohort of pregnant women (n = 3,598), followed-up between 2012 and 2019 at six sites worldwide 4 , we studied the associations between ultrasound-derived fetal cranial growth trajectories, measured longitudinally from <14 weeks' gestation, against international standards 5,6 , and growth and neurodevelopment up to 2 years of age 7,8 . We identified five trajectories associated with specific neurodevelopmental, behavioral, visual and growth outcomes, independent of fetal abdominal growth, postnatal morbidity and anthropometric measures at birth and age 2. The trajectories, which changed within a 20-25-week gestational age window, were associated with brain development at 2 years of age according to a mirror (positive/negative) pattern, mostly focused on maturation of cognitive, language and visual skills. Further research should explore the potential for preventive interventions in pregnancy to improve infant neurodevelopmental outcomes before the critical window of opportunity that precedes the divergence of growth at 20-25 weeks' gestation.
Databáze: MEDLINE