Ophthalmic Assessment in Patients With Darier Disease.

Autor: Hammad H; From the Bruce Rappaport Faculty of Medicine, Technion - Institute of Technology, Haifa, Israel (H.H., E.A., A.Y., D.B., M.Z., R.P.D.-G.); Department of Dermatology, Emek Medical Center, Afula, Israel (H.H., A.Y., M.Z., R.P.D.-G.)., Adler E; From the Bruce Rappaport Faculty of Medicine, Technion - Institute of Technology, Haifa, Israel (H.H., E.A., A.Y., D.B., M.Z., R.P.D.-G.); Department of Ophthalmology, Emek Medical Center, Afula, Israel (L.A.)., Yeshurun A; From the Bruce Rappaport Faculty of Medicine, Technion - Institute of Technology, Haifa, Israel (H.H., E.A., A.Y., D.B., M.Z., R.P.D.-G.); Department of Dermatology, Emek Medical Center, Afula, Israel (H.H., A.Y., M.Z., R.P.D.-G.)., Abayev L; The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel (S.V.)., Vered S; Department of Statistics, Haifa University, Haifa, Israel., Briscoe D; From the Bruce Rappaport Faculty of Medicine, Technion - Institute of Technology, Haifa, Israel (H.H., E.A., A.Y., D.B., M.Z., R.P.D.-G.); Department of Ophthalmology, Emek Medical Center, Afula, Israel (L.A.)., Ziv M; From the Bruce Rappaport Faculty of Medicine, Technion - Institute of Technology, Haifa, Israel (H.H., E.A., A.Y., D.B., M.Z., R.P.D.-G.); Department of Dermatology, Emek Medical Center, Afula, Israel (H.H., A.Y., M.Z., R.P.D.-G.)., Dodiuk-Gad RP; From the Bruce Rappaport Faculty of Medicine, Technion - Institute of Technology, Haifa, Israel (H.H., E.A., A.Y., D.B., M.Z., R.P.D.-G.); Department of Dermatology, Emek Medical Center, Afula, Israel (H.H., A.Y., M.Z., R.P.D.-G.); Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada (R.P.D.-G.).. Electronic address: rdodiukgad@gmail.com.
Jazyk: angličtina
Zdroj: American journal of ophthalmology [Am J Ophthalmol] 2021 Jul; Vol. 227, pp. 139-142. Date of Electronic Publication: 2021 Mar 15.
DOI: 10.1016/j.ajo.2021.03.011
Abstrakt: Purpose: To assess the prevalence of ophthalmic findings in patients with Darier disease, an autosomal dominant genetic skin disorder, in an effort to evaluate the need for eye examinations in the management of the disease.
Design: Prospective observational case series.
Methods: Thirty-six individuals with Darier disease were evaluated by both ocular assessment questionnaire and a comprehensive ophthalmic examination (visual acuity, refraction, external examination, and slit-lamp examination) with emphasis on the eyelids, conjunctiva, and cornea. In addition, questionnaire-based medical interview and skin examination were conducted.
Results: According to the medical questionnaire, 39% of patients reported eye problems, 36% dry eye, and 42% eye fatigue after prolonged reading. Ocular examination revealed Darier disease lesions on the eyelids in 55% of the patients, blepharitis in 44%, conjunctival hyperemia in 28%, and short tear film break-up time in 83%. There was no significant relationship between any of these ophthalmic findings and systemic retinoid therapy, sex, or age.
Conclusions: The high prevalence of blepharitis and dry eye highlights the importance of ophthalmologic evaluation of patients with Darier disease.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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