Efflux Limits Tumor Drug Delivery Despite Disrupted BBB.

Autor: Griffith JI; Brain Barriers Research Center, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA., Sarkaria JN; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Elmquist WF; Brain Barriers Research Center, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA. Electronic address: elmqu011@umn.edu.
Jazyk: angličtina
Zdroj: Trends in pharmacological sciences [Trends Pharmacol Sci] 2021 Jun; Vol. 42 (6), pp. 426-428. Date of Electronic Publication: 2021 Mar 15.
DOI: 10.1016/j.tips.2021.03.001
Abstrakt: Apparent blood-brain barrier (BBB) disruption is common in glioblastoma (GBM), but has not translated to improved drug delivery efficacy. Recently, de Gooijer et al. demonstrated that efflux transporters can have a prominent role in limiting drug delivery. These transport systems contribute to ineffective drug delivery to tumor cells in the brain.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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