Exploring the genotoxicity triggers in the MP UV/H 2 O 2 -chloramination treatment of bisphenol A through bioassay coupled with non-targeted analysis.

Autor: Liu X; College of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China; Bio5 Institute, Department of Chemical and Environmental Engineering, University of Arizona, 1657 E Helen St, Tucson, AZ 85719, United States; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China., Park M; Bio5 Institute, Department of Chemical and Environmental Engineering, University of Arizona, 1657 E Helen St, Tucson, AZ 85719, United States., Beitel SC; Bio5 Institute, Department of Chemical and Environmental Engineering, University of Arizona, 1657 E Helen St, Tucson, AZ 85719, United States., Lopez-Prieto IJ; Bio5 Institute, Department of Chemical and Environmental Engineering, University of Arizona, 1657 E Helen St, Tucson, AZ 85719, United States., Zhu NZ; College of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China; Jiaxing-Tongji Environmental Research Institute, 1994 Linggongtang Road, Jiaxing 314051, Zhejiang Province, China., Meng XZ; College of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China; Jiaxing-Tongji Environmental Research Institute, 1994 Linggongtang Road, Jiaxing 314051, Zhejiang Province, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China. Electronic address: xzmeng@tongji.edu.cn., Snyder SA; Bio5 Institute, Department of Chemical and Environmental Engineering, University of Arizona, 1657 E Helen St, Tucson, AZ 85719, United States. Electronic address: snyders2@email.arizona.edu.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2021 May 15; Vol. 769, pp. 145218. Date of Electronic Publication: 2021 Jan 18.
DOI: 10.1016/j.scitotenv.2021.145218
Abstrakt: Bisphenol A (BPA) is a well-known xenoestrogen, and UV/H 2 O 2 advanced oxidation process (AOP) is one of the most effective technologies to remove BPA from water. Using BPA spiked tap water, a batch-scale photochemical experiment was conducted to investigate whether BPA can pose a genotoxicity concern during the medium pressure (MP) UV/H 2 O 2 treatment and the post-chloramination. Samples at different UV exposure and post-chloramination durations were collected and analyzed by CALUX® gene reporter assays regarding estrogen receptor α (ERα) and p53 transcriptional activity. MP UV/H 2 O 2 process did not cause extra estrogenic effects from the degradation of BPA, whereas genotoxicity occurred when the treated water was exposed with monochloramine. Seven frequently reported nitrogenous disinfection byproducts (N-DBPs) were detected, but none of them were responsible for the observed genotoxicity. Employed with gas chromatography-quadrupole time-of-flight mass spectrometry (GC-QTOF-MS), four compounds possibly contributed to the genotoxicity were tentatively identified and two of them with aminooxy- or cyano- group were considered as "new" N-DBPs. This study demonstrated that by-products differ from their parent compounds in toxicity can be formed in the UV oxidation with post-disinfection process, which should become a cause for concern.
Competing Interests: Declaration of competing interest We declare that we do not have any commercial or associative interest that represents a conflict of interest in connection with the work submitted.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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