Expression of adipocytokines in heart fat depots depending on the degree of coronary artery atherosclerosis in patients with coronary artery disease.

Autor:	Gruzdeva OV; Federal State Budgetary Institution 'Research Institute for Complex Issues of Cardiovascular Disease', Sosnovyi bulvar, Kemerovo, Russian Federation., Belik EV; Federal State Budgetary Institution 'Research Institute for Complex Issues of Cardiovascular Disease', Sosnovyi bulvar, Kemerovo, Russian Federation., Dyleva YA; Federal State Budgetary Institution 'Research Institute for Complex Issues of Cardiovascular Disease', Sosnovyi bulvar, Kemerovo, Russian Federation., Borodkina DA; Federal State Budgetary Institution 'Research Institute for Complex Issues of Cardiovascular Disease', Sosnovyi bulvar, Kemerovo, Russian Federation., Sinitsky MY; Federal State Budgetary Institution 'Research Institute for Complex Issues of Cardiovascular Disease', Sosnovyi bulvar, Kemerovo, Russian Federation., Naumov DY; Federal State Budgetary Institution 'Research Institute for Complex Issues of Cardiovascular Disease', Sosnovyi bulvar, Kemerovo, Russian Federation., Bychkova EE; Federal State Budgetary Institution 'Research Institute for Complex Issues of Cardiovascular Disease', Sosnovyi bulvar, Kemerovo, Russian Federation., Fanaskova EV; Federal State Budgetary Institution 'Research Institute for Complex Issues of Cardiovascular Disease', Sosnovyi bulvar, Kemerovo, Russian Federation., Palicheva EI; Federal State Budgetary Institution 'Research Institute for Complex Issues of Cardiovascular Disease', Sosnovyi bulvar, Kemerovo, Russian Federation., Kuzmina AA; Federal State Budgetary Institution 'Research Institute for Complex Issues of Cardiovascular Disease', Sosnovyi bulvar, Kemerovo, Russian Federation., Karetnikova VN; Federal State Budgetary Institution 'Research Institute for Complex Issues of Cardiovascular Disease', Sosnovyi bulvar, Kemerovo, Russian Federation., Barbarash OL; Federal State Budgetary Institution 'Research Institute for Complex Issues of Cardiovascular Disease', Sosnovyi bulvar, Kemerovo, Russian Federation.
Jazyk:	angličtina
Zdroj:	PloS one [PLoS One] 2021 Mar 18; Vol. 16 (3), pp. e0248716. Date of Electronic Publication: 2021 Mar 18 (Print Publication: 2021).
DOI:	10.1371/journal.pone.0248716
Abstrakt:	In coronary artery disease (CAD) the adipocytokine content in the heart fat depot is altered, but it has not been established whether these changes are associated with the degree of atherosclerotic damage to the coronary artery (CA). Were examined 84 patients with CAD, and according to the degree of atherosclerotic state based on the SYNTAX Score scale, were divided: 39 moderate (≤22 points), 20 severe (23-31 points) and 25 extremely severe (≥32 points). Biopsies of subcutaneous (SAT), epicardial (EAT) and perivascular adipose tissue (PVAT) were obtained during elective coronary artery bypass grafting (CABG). The expression of adipocytokine was determined using real-time PCR. The concentration of the studied adipocytokines in adipocyte culture medium was measured by ELISA. Statistical analysis was performed using logistic regression analysis. In the adipocytes of the cardiac depot of patients with CAD, an increase in the expression and secretion of leptin and IL-6 and a decrease in adiponectin, with a maximum manifestation in severe and extremely severe CA lesions, was observed. EAT adipocytes were characterized by minimal expression of the adiponectin gene maximal gene expression leptin and IL-6 compared to SAT and PVAT adipocytes. Competing Interests: The authors have declared that no competing interests exist.
Databáze:	MEDLINE
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