Neutrophil and Nanoparticles Delivery to Tumor: Is It Going to Carry That Weight?

Autor: Vishnevskiy DA; V. Serbsky National Medical Research Center for Psychiatry and Narcology, Kropotkinskiy Pereulok, 23, Moscow, 119034, Russia.; N. I Pirogov Russian National Research Medical University, Ulitsa Ostrovityanova, 1, Moscow, 117997, Russia., Garanina AS; National University of Science and Technology (MISIS), Leninskiy Prospekt, 4, Moscow, 119049, Russia., Chernysheva AA; V. Serbsky National Medical Research Center for Psychiatry and Narcology, Kropotkinskiy Pereulok, 23, Moscow, 119034, Russia., Chekhonin VP; V. Serbsky National Medical Research Center for Psychiatry and Narcology, Kropotkinskiy Pereulok, 23, Moscow, 119034, Russia.; N. I Pirogov Russian National Research Medical University, Ulitsa Ostrovityanova, 1, Moscow, 117997, Russia., Naumenko VA; V. Serbsky National Medical Research Center for Psychiatry and Narcology, Kropotkinskiy Pereulok, 23, Moscow, 119034, Russia.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2021 May; Vol. 10 (9), pp. e2002071. Date of Electronic Publication: 2021 Mar 18.
DOI: 10.1002/adhm.202002071
Abstrakt: The application of cell carriers for transporting nanodrugs to the tumor draws much attention as the alternative to the passive drug delivery. In this concept, the neutrophil (NΦ) is of special interest as this cell is able to uptake nanoparticles (NPs) and cross the vascular barrier in response to tumor signaling. There is a growing body of literature describing NP-NΦ interactions in vitro and in vivo that demonstrates the opportunity of using these cells to improve the efficacy of cancer therapy. However, a number of conceptual and technical issues need to be resolved for translating the technology into clinics. The current review summarizes the recent advances and challenges associated with NP-NΦ interactions, with the special focus on the complex interplay between the NP internalization pathways and the modulation of NΦ activity, and its potential consequences for nanodrug delivery.
(© 2021 Wiley-VCH GmbH.)
Databáze: MEDLINE
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