Prognostic scoring models in parotid gland carcinoma.

Autor: Westergaard-Nielsen M; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Möller S; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.; OPEN - Open Patient data Explorative Network, Odense University Hospital, Odense, Denmark., Godballe C; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Grau Eriksen J; Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark., Larsen SR; Department of Pathology, Odense University Hospital, Odense, Denmark., Kiss K; Department of Pathology, Rigshospitalet, Copenhagen, Denmark., Agander T; Department of Pathology, Rigshospitalet, Copenhagen, Denmark., Parm Ulhøi B; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark., Charabi B; Department of Otorhinolaryngology, Head and Neck Surgery, Rigshospitalet, Copenhagen, Denmark., Ehlers Klug T; Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Aarhus, Denmark., Jacobsen H; Department of Otorhinolaryngology, Head and Neck Surgery, Aalborg University Hospital, Aalborg, Denmark., Johansen J; Department of Oncology, Odense University Hospital, Odense, Denmark., Kristensen CA; Department of Oncology, Rigshospitalet, Copenhagen, Denmark., Andersen E; Department of Oncology, Herlev Hospital, Herlev, Denmark., Andersen M; Department of Oncology, Aalborg University Hospital, Aalborg, Denmark., Bjørndal K; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2021 Jul; Vol. 43 (7), pp. 2081-2090. Date of Electronic Publication: 2021 Mar 18.
DOI: 10.1002/hed.26672
Abstrakt: Background: The aim was to identify prognostic factors and test three prognostic scoring models that predicted the risk of recurrence in patients with parotid gland carcinoma.
Methods: All Danish patients with parotid gland carcinoma, treated with curative intent, from 1990 to 2015 (n = 726) were included. Potential prognostic factors were evaluated using Cox regression and competing risk analyses. The concordance of each prognostic model was estimated using Harrel's C index.
Results: The study population consisted of 344 men and 382 women, with a median age of 63 years. Age above 60 years, high grade histology, T3/T4 tumor, regional lymph node metastases, and involved surgical margins were all associated with a significant reduction in recurrence-free survival. The prognostic model that agreed best with actual outcomes had a C-index of 0.76.
Conclusion: Prognostic scoring models may improve individualized follow-up strategies after curatively intended treatment for patients with parotid gland carcinoma.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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