Insecticide susceptibility of Phlebotomus argentipes sandflies, vectors of visceral leishmaniasis in India.

Autor: Dinesh DS; Division of Vector Biology and Control, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India., Hassan F; Division of Vector Biology and Control, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India., Kumar V; Division of Vector Biology and Control, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India., Kesari S; Division of Vector Biology and Control, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India., Topno RK; Division of Vector Biology and Control, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India., Yadav RS; Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.
Jazyk: angličtina
Zdroj: Tropical medicine & international health : TM & IH [Trop Med Int Health] 2021 Jul; Vol. 26 (7), pp. 823-828. Date of Electronic Publication: 2021 Apr 15.
DOI: 10.1111/tmi.13576
Abstrakt: Objectives: Indoor residual spraying (IRS) with insecticides is the main vector control intervention for the elimination of visceral leishmaniasis in India. After a change in IRS policy in 2015 due to widespread resistance of Phlebotomus argentipes to DDT, IRS with DDT was replaced with alpha-cypermethrin IRS in 2016. The objective of the present study was to evaluate the susceptibility of P. argentipes to DDT and its alternatives, namely malathion and pirimiphos-methyl (organophosphates); alpha-cypermethrin, deltamethrin, lambda-cyhalothrin and permethrin (pyrethroids), and bendiocarb and propoxur (carbamates), in support of visceral leishmaniasis elimination in India.
Methods: Phlebotomus argentipes sandflies were collected from the visceral-leishmaniasis endemic states of Bihar, Jharkhand and West Bengal. In the WHO tube tests, the phenotypic susceptibility of F1, 2-day old, non-blood fed females were determined against filter papers impregnated with DDT 4%, malathion 5%, pirimiphos-methyl 0.25%, alpha-cypermethrin 0.05%, deltamethrin 0.05%, lambda-cyhalothrin 0.05%, permethrin 0.75%, bendiocarb 0.1% and propoxur 0.1%, which were sourced from Universiti Sains Malaysia. The knockdown of sandflies after 1-h exposure and mortality at 24 h after the 1-h exposure period were scored.
Results: Mean mortality of P. argentipes 24 h after exposure in tube tests was 22.6% for DDT and ≥ 98% for other insecticide-impregnated papers tested.
Conclusion: Phlebotomus argentipes continues to be highly resistant to DDT with no reversal of resistance after DDT's withdrawal from IRS. P. argentipes was fully susceptible to pyrethroid, organophosphate and carbamate insecticides tested. Regular monitoring is warranted for insecticide resistance management in sandfly vectors.
(© 2021 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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