Kinetics of Immunoglobulins in Septic Shock Patients Treated With an IgM- and IgA-Enriched Intravenous Preparation: An Observational Study.
Autor: | Berlot G; Department of Anesthesia and Intensive Care, Cattinara Hospital, University of Trieste, Trieste, Italy., Scamperle A; Department of Anesthesia and Intensive Care, Cattinara Hospital, University of Trieste, Trieste, Italy., Istrati T; Department of Anesthesia and Intensive Care, Cattinara Hospital, University of Trieste, Trieste, Italy., Dattola R; Department of Anesthesia and Intensive Care, Cattinara Hospital, University of Trieste, Trieste, Italy., Longo I; Department of Anesthesia and Intensive Care, Cattinara Hospital, University of Trieste, Trieste, Italy., Chillemi A; Department of Anesthesia and Intensive Care, Cattinara Hospital, University of Trieste, Trieste, Italy., Baronio S; Department of Anesthesia and Intensive Care, Cattinara Hospital, University of Trieste, Trieste, Italy., Quarantotto G; Department of Anesthesia and Intensive Care, Cattinara Hospital, University of Trieste, Trieste, Italy., Zanchi S; Department of Anesthesia and Intensive Care, Cattinara Hospital, University of Trieste, Trieste, Italy., Roman-Pognuz E; Department of Anesthesia and Intensive Care, Cattinara Hospital, University of Trieste, Trieste, Italy., Bixio M; Department of Anesthesia and Intensive Care, San Martino Hospital, Genova, Italy., Tomasini A; Department of Anesthesia and Intensive Care, Cattinara Hospital, University of Trieste, Trieste, Italy. |
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Jazyk: | angličtina |
Zdroj: | Frontiers in medicine [Front Med (Lausanne)] 2021 Mar 01; Vol. 8, pp. 605113. Date of Electronic Publication: 2021 Mar 01 (Print Publication: 2021). |
DOI: | 10.3389/fmed.2021.605113 |
Abstrakt: | Objective: To assess the variations of the blood levels of immunoglobulins (Ig) in septic shock patients treated with an Ig preparation enriched in IgM and IgA (eIg). Design: The blood levels of Ig in survivors (S) and non-survivors (NS) of a group of septic shock patients were measured before the initial administration (D0) and 1 (D1), 4 (D4), and 7 (D7) days thereafter. The SAPS II score, the capillary permeability, the primary site of infection, the antibiotic appropriateness, and the outcome at 28 days were also assessed. Results: In the interval D0-D7, the IgM increased significantly only in the S while remained stable in NS; the IgA significantly increased in both groups; the IgG did not vary significantly in both groups. At D4, the capillary permeability significantly decreased in S but not in NS. Conclusions: The kinetics of the different classes of Ig after eIg were different between S and NS. This could be related either to (a) different capillary permeability in the two groups or to (b) higher Ig consumption in NS. Further studies to confirm the benefits of eIg in the treatment of sepsis syndrome and to define the specific target population and the correct eIg dose are warranted. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Berlot, Scamperle, Istrati, Dattola, Longo, Chillemi, Baronio, Quarantotto, Zanchi, Roman-Pognuz, Bixio and Tomasini.) |
Databáze: | MEDLINE |
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