Neuroprotective effects of ethanolic extract from dry Rhodiola rosea L. rhizomes.

Autor: Kim KJ; Department of Food Science and Biotechnology, Kyung Hee University, Yongin, 17104 Republic of Korea., Jung YS; Korea Food Research Institute, Wanju, 55365 Republic of Korea., You DM; Food R&D Center, SK Bioland Co., Ltd., Ansan, 15407 Republic of Korea., Lee SH; Food R&D Center, SK Bioland Co., Ltd., Ansan, 15407 Republic of Korea., Lee G; Department of Herbology, College of Korean Medicine, Wonkwang University, Iksan, 54538 Republic of Korea., Kwon KB; Department of Korean Physiology, College of Korean Medicine, Wonkwang University, Iksan, 54538 Republic of Korea., Kim DO; Department of Food Science and Biotechnology, Kyung Hee University, Yongin, 17104 Republic of Korea.; Skin Biotechnology Center, Kyung Hee University, Suwon, 16229 Republic of Korea.
Jazyk: angličtina
Zdroj: Food science and biotechnology [Food Sci Biotechnol] 2021 Feb 05; Vol. 30 (2), pp. 287-297. Date of Electronic Publication: 2021 Feb 05 (Print Publication: 2021).
DOI: 10.1007/s10068-020-00868-7
Abstrakt: Rhodiola rosea L. rhizome has been used as a traditional medicine to treat fatigue, depression, and cognitive dysfunction. We aimed to authenticate R. rosea L. rhizome using the DNA barcoding technique and to quantify its main compounds, total phenolics, total flavonoids, and antioxidant capacity, and then to investigate their neuroprotective effects. The sequences of internal transcribed spacer and trnH-psbA of R. rosea L. rhizomes showed a 99% identity with those of NCBI GenBank database according to BLAST searches. Analysis using reversed-phase HPLC revealed five main compounds in R. rosea L. rhizome. Rhodiola rosea L. rhizome and two bioactive compounds, salidroside and tyrosol, showed free radical scavenging activity. Rhodiola rosea L . rhizome and its identified compounds protected neuronal PC-12 cells against oxidative stress and showed moderate acetylcholinesterase inhibition. Taken together, these results suggest that R. rosea L . rhizomes with bioactives can be used as a functional ingredient with potential for neuroprotection.
Supplementary Information: The online version of this article (doi:10.1007/s10068-020-00868-7) contains supplementary material, which is available to authorized users.
Competing Interests: Conflict of interestThe authors declare no conflict of interests.
(© The Korean Society of Food Science and Technology 2021.)
Databáze: MEDLINE
Externí odkaz: