Transmission dynamics and timing of key events for SARS-CoV-2 infection in healthcare workers.

Autor: Emecen AN; Department of Public Health, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey., Basoglu Sensoy E; Department of Public Health, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey., Sezgin E; Department of Public Health, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey., Yildirim Ustuner B; Department of Public Health, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey., Keskin S; Department of Public Health, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey., Siyve N; Department of Public Health, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey., Celik SG; Department of Public Health, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey., Bayrak G; Department of Public Health, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey., Senturk Durukan N; Department of Public Health, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey., Coskun Beyan A; Department of Occupational Medicine, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey., Ergor A; Department of Public Health, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey.; Department of Occupational Medicine, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey., Unal B; Department of Public Health, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey., Ergor G; Department of Public Health, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey.
Jazyk: angličtina
Zdroj: Infectious diseases (London, England) [Infect Dis (Lond)] 2021 Jul; Vol. 53 (7), pp. 531-537. Date of Electronic Publication: 2021 Mar 17.
DOI: 10.1080/23744235.2021.1900599
Abstrakt: Background: Healthcare workers (HCWs) have increased risk for SARS-CoV-2 infection via contacts in hospitals, as well as via transmission in the community. Serial interval, which is defined as the time between symptom onsets in an infector-infectee pair, and the incubation period are key parameters in determining the control strategies for COVID-19. This study aimed to evaluate surveillance of HCWs and estimate the serial interval and incubation period of COVID-19.
Methods: A total of 149 HCWs and 36 certain infector-infectee pairs between 19th March 2020 and 1st November 2020 in a university hospital were included in the study. Epidemiological characteristics were recorded. Serial interval and incubation period were estimated using parametric accelerated failure time models.
Results: Forty HCWs (26.8%) were detected via contact-based surveillance. Of 100 HCWs epidemiologically linked with a confirmed COVID-19 case, 36 (36%) had contact with a colleague. The median serial interval was 3.93 days (95% CI: 3.17-4.83). Of symptomatic HCWs, 97.5% had developed symptoms 13.71 (95% CI: 9.39-18.73) days after symptom onset of the primary case. The median incubation period was 3.99 (95% CI: 3.25-4.84) days. Of symptomatic HCWs, 97.5% developed symptoms within 9.49 (95% CI: 6.75-12.20) days after infection.
Conclusions: The serial interval and the incubation period of COVID-19 in HCWs were shorter than in the general population. Rigorous contact tracing and isolation of infected HCWs could have resulted in shorter serial intervals. Implementation of more stringent in-hospital control measures focussed on transmission between HCWs should be considered.
Databáze: MEDLINE
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