Clinical and Epidemiological Findings from Enhanced Monkeypox Surveillance in Tshuapa Province, Democratic Republic of the Congo During 2011-2015.

Autor:	Whitehouse ER; Epidemic Intelligence Service, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Division of High Consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Bonwitt J; Division of High Consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Hughes CM; Division of High Consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Lushima RS; Ministère de la Santé Publique, Kinshasa, Democratic Republic of the Congo., Likafi T; Ecole de Santé Publique de Kinshasa, Kinshasa, Democratic Republic of the Congo., Nguete B; Ecole de Santé Publique de Kinshasa, Kinshasa, Democratic Republic of the Congo., Kabamba J; US Centers for Disease Control and Prevention, Kinshasa, Democratic Republic of the Congo., Monroe B; Division of High Consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Doty JB; Division of High Consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Nakazawa Y; Division of High Consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Damon I; Division of High Consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Malekani J; Faculty of Science, University of Kinshasa, Kinshasa, Democratic Republic of the Congo., Davidson W; Division of High Consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Wilkins K; Division of High Consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Li Y; Division of High Consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Radford KW; Division of Viral Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia,USA., Schmid DS; Division of Viral Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia,USA., Pukuta E; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo., Muyamuna E; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo., Karhemere S; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo., Tamfum JM; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo., Okitolonda EW; Ecole de Santé Publique de Kinshasa, Kinshasa, Democratic Republic of the Congo., McCollum AM; Division of High Consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Reynolds MG; Division of High Consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2021 Jun 04; Vol. 223 (11), pp. 1870-1878.
DOI:	10.1093/infdis/jiab133
Abstrakt:	Background: Monkeypox is a poorly described emerging zoonosis endemic to Central and Western Africa. Methods: Using surveillance data from Tshuapa Province, Democratic Republic of the Congo during 2011-2015, we evaluated differences in incidence, exposures, and clinical presentation of polymerase chain reaction-confirmed cases by sex and age. Results: We report 1057 confirmed cases. The average annual incidence was 14.1 per 100 000 (95% confidence interval, 13.3-15.0). The incidence was higher in male patients (incidence rate ratio comparing males to females, 1.21; 95% confidence interval, 1.07-1.37), except among those 20-29 years old (0.70; .51-.95). Females aged 20-29 years also reported a high frequency of exposures (26.2%) to people with monkeypox-like symptoms.The highest incidence was among 10-19-year-old males, the cohort reporting the highest proportion of animal exposures (37.5%). The incidence was lower among those presumed to have received smallpox vaccination than among those presumed unvaccinated. No differences were observed by age group in lesion count or lesion severity score. Conclusions: Monkeypox incidence was twice that reported during 1980-1985, an increase possibly linked to declining immunity provided by smallpox vaccination. The high proportion of cases attributed to human exposures suggests changing exposure patterns. Cases were distributed across age and sex, suggesting frequent exposures that follow sociocultural norms. (Published by Oxford University Press for the Infectious Diseases Society of America 2021.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu