Virtual Rehabilitation in Parkinson Disease: A Dopamine Transporter Imaging Study.

Autor:	Toldo JMP; From the Hospital Israelita Albert Einstein, São Paulo, Brazil (JMPT, MA, GCCN, TV, SAN, EAJ, ACF); Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo, São Paulo, Brazil (RAS, SMCAS); and Universidade Federal de São Paulo, São Paulo, Brazil (RAS, SMCAS, HBF)., Arjona M, Campos Neto GC, Vitor T, Nogueira SA, Amaro E Jr, Saba RA, Silva SMCA, Ferraz HB, Felício AC
Jazyk:	angličtina
Zdroj:	American journal of physical medicine & rehabilitation [Am J Phys Med Rehabil] 2021 Apr 01; Vol. 100 (4), pp. 359-366.
DOI:	10.1097/PHM.0000000000001574
Abstrakt:	Objective: The aim of the study was to verify the effect of a virtual rehabilitation protocol for patients with Parkinson disease, primarily assessing striatal dopamine transporters and secondarily motor symptoms and quality of life. Design: Nineteen patients with Parkinson disease underwent an 8-wk virtual rehabilitation protocol using XBOX 360S. Evaluation of dopamine transporters was performed by single-photon emission computed tomography using TRODAT-1 as the radioligand. Participants were clinically assessed using the Unified Parkinson Disease Rating Scale to quantify motor symptoms. Moreover, the Parkinson Disease Questionnaire and Short-Form Health Status Survey were used to assess quality of life and the Berg Balance Scale to assess balance. Results: Regarding our primary outcome, dopamine transporter was significantly increased in the putamen contralateral to the clinically most affected body side (P = 0.034) considering preintervention and postintervention measurements. Furthermore, we observed significant improvement in Unified Parkinson Disease Rating Scale (10-point reduction, P = 0.001), Parkinson Disease Questionnaire (11.3-point reduction, P = 0.001), Short-Form Health Status Survey ("Functional capacity," P = 0.001; "Pain," P = 0.006; and "Mental Health" domains, P < 0.001), and Berg Balance Scale (5-point increase, P = 0.015). Conclusions: In our group of Parkinson disease patients, this virtual rehabilitation protocol enabled a dopamine transporter increase in the region of the putamen contralateral to the clinically most affected body side. Moreover, motor signs and quality of life were significantly improved. Competing Interests: Financial disclosure statements have been obtained, and no conflicts of interest have been reported by the authors or by any individuals in control of the content of this article. (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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