Adolescent intermittent ethanol exposure induces sex-dependent divergent changes in ethanol drinking and motor activity in adulthood in C57BL/6J mice.

Autor: Maldonado-Devincci AM; Department of Psychology, College of Health and Human Sciences, North Carolina Agricultural and Technical State University, Greensboro, NC, USA., Makdisi JG; Department of Social Work and Sociology, College of Health and Human Sciences, North Carolina Agricultural and Technical State University, Greensboro, NC, USA., Hill AM; Department of Psychology, College of Health and Human Sciences, North Carolina Agricultural and Technical State University, Greensboro, NC, USA.; The Gerontology Institute, College of Arts and Science, Georgia State University, Atlanta, GA, USA., Waters RC; Department of Psychology, College of Health and Human Sciences, North Carolina Agricultural and Technical State University, Greensboro, NC, USA.; Department of Psychology, Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA., Hall NI; Department of Biology, College of Science and Technology, North Carolina Agricultural and Technical State University, Greensboro, NC, USA.; Department of Neuroscience, Biomedical Graduate Education, Georgetown University, Washington, DC, USA., Shobande MJ; Department of Bioengineering, College of Engineering, North Carolina Agricultural and Technical State University, Greensboro, NC, USA., Kumari A; Department of Biology, College of Science and Technology, North Carolina Agricultural and Technical State University, Greensboro, NC, USA.
Jazyk: angličtina
Zdroj: Journal of neuroscience research [J Neurosci Res] 2022 Aug; Vol. 100 (8), pp. 1560-1572. Date of Electronic Publication: 2021 Mar 16.
DOI: 10.1002/jnr.24814
Abstrakt: With alcohol readily accessible to adolescents, its consumption leads to many adverse effects, including impaired learning, attention, and behavior. Adolescents report higher rates of binge drinking compared to adults. They are also more prone to substance use disorder in adulthood due to physiological changes during the adolescent developmental period. We used C57BL/6J male and female mice to investigate the long-lasting impact of binge ethanol exposure during adolescence on voluntary ethanol intake and open field behavior during later adolescence (Experiment 1) and during emerging adulthood (Experiment 2). The present set of experiments were divided into four stages: (1) adolescent intermittent vapor inhalation exposure, (2) abstinence, (3) voluntary ethanol intake, and (4) open field behavioral testing. During adolescence, male and female mice were exposed to air or ethanol using intermittent vapor inhalation from postnatal day (PND) 28-42. Following this, mice underwent short-term abstinence from PND 43-49 (Experiment 1) or protracted abstinence from PND 43-69 (Experiment 2). Beginning on PND 50-76 or PND 70-97, mice were assessed for intermittent voluntary ethanol consumption using a two-bottle choice drinking procedure over 28 days. Male adolescent ethanol-exposed mice showed increased ethanol consumption following short-term abstinence and following protracted abstinence. In contrast, female mice showed no changes in ethanol consumption following short-term abstinence and decreased ethanol consumption following protracted abstinence. There were modest changes in open field behavior following voluntary ethanol consumption in both experiments. These data demonstrate a sexually divergent shift in ethanol consumption following binge ethanol exposure during adolescence and differences in open field behavior. These results highlight sex-dependent vulnerability to developing substance use disorders in adulthood.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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