Molecular Dambusters: What Is Behind Hyperpermeability in Bradykinin-Mediated Angioedema?

Autor: Debreczeni ML; Research Laboratory, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.; ELKH-SE Research Group of Immunology and Haematology, Eötvös Loránd Research Network and Semmelweis University, Budapest, Hungary., Németh Z; Research Laboratory, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary., Kajdácsi E; Research Laboratory, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary., Farkas H; Research Laboratory, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.; Hungarian Angioedema Center of Reference and Excellence, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary., Cervenak L; Research Laboratory, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary. cervenak.laszlo@med.semmelweis-univ.hu.
Jazyk: angličtina
Zdroj: Clinical reviews in allergy & immunology [Clin Rev Allergy Immunol] 2021 Jun; Vol. 60 (3), pp. 318-347. Date of Electronic Publication: 2021 Mar 16.
DOI: 10.1007/s12016-021-08851-8
Abstrakt: In the last few decades, a substantial body of evidence underlined the pivotal role of bradykinin in certain types of angioedema. The formation and breakdown of bradykinin has been studied thoroughly; however, numerous questions remained open regarding the triggering, course, and termination of angioedema attacks. Recently, it became clear that vascular endothelial cells have an integrative role in the regulation of vessel permeability. Apart from bradykinin, a great number of factors of different origin, structure, and mechanism of action are capable of modifying the integrity of vascular endothelium, and thus, may participate in the regulation of angioedema formation. Our aim in this review is to describe the most important permeability factors and the molecular mechanisms how they act on endothelial cells. Based on endothelial cell function, we also attempt to explain some of the challenging findings regarding bradykinin-mediated angioedema, where the function of bradykinin itself cannot account for the pathophysiology. By deciphering the complex scenario of vascular permeability regulation and edema formation, we may gain better scientific tools to be able to predict and treat not only bradykinin-mediated but other types of angioedema as well.
(© 2021. The Author(s).)
Databáze: MEDLINE
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