Activation of TLR4 of Mesenchymal Stem Cells Enhances the Regenerative Properties of Their Secretomes.

Autor: Rusanov AL; V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia. alexander.l.rusanov@gmail.com., Biryukova YK; Perspectiva Research-and-Production Company, Novosibirsk, Russia., Shoshina OO; Perspectiva Research-and-Production Company, Novosibirsk, Russia., Luzgina ED; V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia., Luzgina NG; V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2021 Feb; Vol. 170 (4), pp. 544-549. Date of Electronic Publication: 2021 Mar 16.
DOI: 10.1007/s10517-021-05103-9
Abstrakt: Mesenchymal stem cells (MSC), like macrophages, can be polarized in vitro. In particular, activation of type 4 Toll-like receptor in MSC leads to the appearance of the so-called "proinflammatory" MSC phenotype (MSC1). We showed that secretome (conditioned media) of MSC1 can affect the wound healing processes: promote healing and modulate exudative inflammation and subsequent fibroplastic processes in the damaged area. These effects of secretomes of polarized MSC were superior to those of intact MSC.
Databáze: MEDLINE
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