Exposure to Propylparaben During Pregnancy and Lactation Induces Long-Term Alterations to the Mammary Gland in Mice.

Autor:	Mogus JP; Department of Environmental Health Sciences, School of Public Health & Health Sciences, University of Massachusetts, Amherst, MA 01003, USA., LaPlante CD; Department of Environmental Health Sciences, School of Public Health & Health Sciences, University of Massachusetts, Amherst, MA 01003, USA., Bansal R; Department of Environmental Health Sciences, School of Public Health & Health Sciences, University of Massachusetts, Amherst, MA 01003, USA., Matouskova K; Department of Environmental Health Sciences, School of Public Health & Health Sciences, University of Massachusetts, Amherst, MA 01003, USA., Schneider BR; Biospecimen Resource and Molecular Analysis Facility, Baystate Medical Center, Springfield, MA 01199, USA., Daniele E; Department of Veterinary & Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA., Silva SJ; Department of Environmental Health Sciences, School of Public Health & Health Sciences, University of Massachusetts, Amherst, MA 01003, USA., Hagen MJ; Department of Veterinary & Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA., Dunphy KA; Department of Veterinary & Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA., Jerry DJ; Department of Veterinary & Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA.; Pioneer Valley Life Sciences Institute, Springfield, MA 01199, USA., Schneider SS; Biospecimen Resource and Molecular Analysis Facility, Baystate Medical Center, Springfield, MA 01199, USA., Vandenberg LN; Department of Environmental Health Sciences, School of Public Health & Health Sciences, University of Massachusetts, Amherst, MA 01003, USA.
Jazyk:	angličtina
Zdroj:	Endocrinology [Endocrinology] 2021 Jun 01; Vol. 162 (6).
DOI:	10.1210/endocr/bqab041
Abstrakt:	The mammary gland is a hormone sensitive organ that is susceptible to endocrine-disrupting chemicals (EDCs) during the vulnerable periods of parous reorganization (ie, pregnancy, lactation, and involution). Pregnancy is believed to have long-term protective effects against breast cancer development; however, it is unknown if EDCs can alter this effect. We examined the long-term effects of propylparaben, a common preservative used in personal care products and foods, with estrogenic properties, on the parous mouse mammary gland. Pregnant BALB/c mice were treated with 0, 20, 100, or 10 000 µg/kg/day propylparaben throughout pregnancy and lactation. Unexposed nulliparous females were also evaluated. Five weeks post-involution, mammary glands were collected and assessed for changes in histomorphology, hormone receptor expression, immune cell number, and gene expression. For several parameters of mammary gland morphology, propylparaben reduced the effects of parity. Propylparaben also increased proliferation, but not stem cell number, and induced modest alterations to expression of ERα-mediated genes. Finally, propylparaben altered the effect of parity on the number of several immune cell types in the mammary gland. These results suggest that propylparaben, at levels relevant to human exposure, can interfere with the effects of parity on the mouse mammary gland and induce long-term alterations to mammary gland structure. Future studies should address if propylparaben exposures negate the protective effects of pregnancy on mammary cancer development. (© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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